Protein Alignment spas and mei-1

DIOPT Version :10

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001370150.1
• Gene: mei-1 / 172612
• WormBaseID: WBGene00003183
• Length: 475
• Species: Caenorhabditis elegans
• Alignment Length: 504
• Identity: 167/504 - (33%)
• Similarity: 249/504 - (49%)
• Gaps: 84/504 - (16%)

  Fly   277 WSGRGDVWDRAQRLHDKMQTNLSMA-RD----RLHFLALREQDLQMQRLSLK-EKQKEEAQSK-- 333
            |:..||:  ..|.:.|.....:|.: ||    |..||...|.:|::.:.::: |....||.::
 Worm    28 WNEAGDL--LRQLMTDVKSCKISASNRDEHDARNTFLRALEANLKLVQQNVRDEDDLHEAMTRQS 90

  Fly   334 --PQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLP 396
              |:...:|.:....:.|:.   .||.:|  ||          |..:|:..|           .|
 Worm    91 GSPEPPADPDVWSKPSPPLP---SSSKFG--AT----------KKGVGAAGP-----------RP 129

  Fly   397 RNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGV 461
            |.:...||          :.:|.||      ..:...|.:...|.|:.|.|...::.....|:.|
 Worm   130 REISKSTS----------SMSTNPA------DVKPANPTQGILPQNSAGDSFDASAYDAYIVQAV 178

  Fly   462 EQKLV-----QLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLL 521
            ...:.     .:.||            ||.|....||.|.|.|.||.:.||.|.|||:|.|.::|
 Worm   179 RGTMATNTENTMSLD------------DIIGMHDVKQVLHEAVTLPLLVPEFFQGLRSPWKAMVL 231

  Fly   522 FGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDS 586
            .||||.||||:|||:|:|.|:||..:|:..|:||:.||.||:||.||.:||...||||||||:|:
 Worm   232 AGPPGTGKTLIARAIASESSSTFFTVSSTDLSSKWRGDSEKIVRLLFELARFYAPSIIFIDEIDT 296

  Fly   587 LLSER-SSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSL 650
            |..:| :|.|||||||:|:||||:.||.....|..|:.||||||.|.|||||..|||.||:::.|
 Worm   297 LGGQRGNSGEHEASRRVKSEFLVQMDGSQNKFDSRRVFVLAATNIPWELDEALRRRFEKRIFIPL 361

  Fly   651 PDEQTRELLLNRLLQKQGSPLDTEA-LRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCL 714
            ||...|:.|:.:.:  :|:|...|. ...||..|:|:||:|:.:|.:.||:..:|.......|.|
 Worm   362 PDIDARKKLIEKSM--EGTPKSDEINYDDLAARTEGFSGADVVSLCRTAAINVLRRYFRYDTKSL 424

  Fly   715 DISAMRAITEQ---------DFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            ....:.|..|.         ||.::|:.:..|..|.::...::|...:|
 Worm   425 RGGELTAAMESLKAELVRNIDFEAALQAVSPSAGPDTMLKCKEWCDSFG 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	9/35 (26%)
		RecA-like_spastin	484..648	CDD:410932	94/164 (57%)
		AAA_lid_3	676..727	CDD:465537	15/59 (25%)
		Vps4_C	<722..754	CDD:462762	7/40 (18%)
mei-1	NP_001370150.1	SpoVK	53..414	CDD:440232	148/416 (36%)
		RecA-like_VPS4-like	195..359	CDD:410917	93/163 (57%)