DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and cdc-48.3

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_492211.1	Gene:	cdc-48.3 / 172586	WormBaseID:	WBGene00010562	Length:	724	Species:	Caenorhabditis elegans

Alignment Length:	251	Identity:	99/251 - (39%)
Similarity:	143/251 - (56%)	Gaps:	18/251 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 GVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFT--GLRAPAKGLLLF 522
            |:.|.::::         ..|.|.||.|.:..|..:|:.||.|...||.|.  |:..|| |:||:
Worm   445 GIRQFILEV---------PNVSWNDIGGNEELKLEIQQAVIWPQKHPEAFERFGIDPPA-GILLY 499

  Fly   523 GPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSL 587
            ||||..|||:|||:|:|....||.:....|.||:|||.||.:|.||:.||.:.|:|:|.||:|::
Worm   500 GPPGCSKTLIARALASEAKMNFLAVKGPELFSKWVGDSEKAIRDLFSRARQVAPTIVFFDEIDAV 564

  Fly   588 LSERSSSEHE-ASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVS 649
            .|.|.|.:.. .|.|:..:.|.|.|||   ....|:::|||||||.:||.|.||  |..:.:||.
Worm   565 GSSRGSEKSSGVSDRVLAQLLTELDGL---EKSSRVILLAATNRPDQLDSALLRPGRLDRAIYVG 626

  Fly   650 LPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRE 705
            ||.|.||..:|....:|.........:.:|.:.|.||||::|.|:.:.||:..:||
Worm   627 LPCEVTRRAILEMRTKKMKFDDTVRTIDKLVEKTSGYSGAELVAVCRTAAMFAMRE 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	28/57 (49%)
		AAA	515..652	CDD:214640	65/139 (47%)
		AAA	519..650	CDD:278434	61/133 (46%)
		Vps4_C	<722..754	CDD:286426
cdc-48.3	NP_492211.1	TIP49	<247..720	CDD:332389	99/251 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810