DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and SPATA5

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_016863314.1	Gene:	SPATA5 / 166378	HGNCID:	18119	Length:	917	Species:	Homo sapiens

Alignment Length:	688	Identity:	179/688 - (26%)
Similarity:	268/688 - (38%)	Gaps:	179/688 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 YLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLS----------NQ 196
            |...::|:|.:..          :..:||||........::.   .|...||.          .|
Human   324 YFISSTTRVNFTE----------IDKNSKEQDNQFKVTYDMI---GGLSSQLKAIREIIELPLKQ 375

  Fly   197 PQRFRPI---QPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAF-------EYISK--------- 242
            |:.|:..   .|..:....|     ||.|..::|:...:...|:       |.|||
Human   376 PELFKSYGIPAPRGVLLYGP-----PGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKL 435

  Fly   243 -------------ALKIDE-----------ENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDV 283
                         .:.|||           :||..|.:...|.     .|.|||..:...|:..|
Human   436 RQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLL-----TLMDGIGSEVSEGQVLV 495

  Fly   284 WDRAQRLH------------DK-MQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQ 335
            .....|.|            || ::..:..|:|||..|         |:|
Human   496 LGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDIL---------QKL--------------- 536

  Fly   336 KTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLG 400
            ..|.|.|   ..|...|::.:|.:|                .:|:    :|.|........|.|.
Human   537 LRRVPHL---LTEAELLQLANSAHG----------------YVGA----DLKVLCNEAAGTRILK 578

  Fly   401 SKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKL 465
            :...|.|......:|.....|:||......|.|..:.             |....:::|...|.:
Human   579 AHMYVSAFATGLTQTPQGLCALRRILKKQPNLPDVKV-------------AGLVKITLKDFLQAM 630

  Fly   466 VQL---ILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELF--TGLRAPAKGLLLFGPP 525
            ..:   .:.||......|.|:||.|.:..|..|::.|..|...||.|  .|:: |.||:||:|||
Human   631 NDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQ-PPKGVLLYGPP 694

  Fly   526 GNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSE 590
            |..||::|:|:|.|....||.|....|.:||||:.|:.||..|..||.:.|||||.||:|:|..|
Human   695 GCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVE 759

  Fly   591 RSSS--EHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLP 651
            |.||  ....:.|:..:.|.|.||:....|   :.:|||||||..:|:|.:|  |..:.:||.||
Human   760 RGSSLGAGNVADRVLAQLLTEMDGIEQLKD---VTILAATNRPDRIDKALMRPGRIDRIIYVPLP 821

  Fly   652 DEQTRELLLNRLLQKQGSPLDTEA-LRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLD 715
            |..||..:..  ||....|:..|. |..|...||.|||:::.|:.::|||..:.|         |
Human   822 DAATRREIFK--LQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLALEE---------D 875

  Fly   716 ISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDY 753
            |.| ..|.::.|..:|.    :|.|:...|..::.:||
Human   876 IQA-NLIMKRHFTQALS----TVTPRIPESLRRFYEDY 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	26/130 (20%)
		P-loop_NTPase	482..>538	CDD:304359	25/57 (44%)
		AAA	515..652	CDD:214640	62/140 (44%)
		AAA	519..650	CDD:278434	58/134 (43%)
		Vps4_C	<722..754	CDD:286426	8/32 (25%)
SPATA5	XP_016863314.1	CDC48_N	65..133	CDD:389870
SPATA5	XP_016863314.1	CDC48	<323..913	CDD:273521	179/688 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810