DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and AgaP_AGAP001612

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_321486.4	Gene:	AgaP_AGAP001612 / 1281560	VectorBaseID:	AGAP001612	Length:	835	Species:	Anopheles gambiae

Alignment Length:	492	Identity:	140/492 - (28%)
Similarity:	216/492 - (43%)	Gaps:	102/492 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 MQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGY-GPKATTSAQP---TASGRKLT 377
            |..:|.:.:.|........|..||::..:.|..: ..|.:.|: ..:.|.|.|.   |..||:.
Mosquito   369 MTSISSQTETKLSTAFNKAKVCEPLIICLENFEV-FGVDNEGHEDQRITGSFQAELMTLFGRQY- 431

  Fly   378 IGSKRPVNLAVANKSQTLPRNLGSKTSVG-AVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPI 441
              |...|.:||||:.::   |....||:. .|.:..|.|.|....:.|..|.|     .|.|.|:
Mosquito   432 --SHPVVVVAVANQKES---NTPKLTSLFLEVIQLHAPTTAERLELLRWISLG-----HRYRLPV 486

  Fly   442 NNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGA---------------------------- 478
                     |....::.:.....|..|   |::.|.|
Mosquito   487 ---------AQLQKIAEQSQGFTLADL---ELLYGNALEAWRRSQDTGRVGLNHFLALLDHMQST 539

  Fly   479 -----------KVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLL 532
                       ||.|::|.|....|..:|..:.|| :|.:...|......|:||:||||.||||:
Mosquito   540 FSDSLGAPKVPKVLWSEIGGLAKLKSEIQNSIGLP-LRHKHLMGKNMRRSGILLYGPPGTGKTLI 603

  Fly   533 ARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSER--SSSE 595
            |:||||||:.:||::....|.:.|||..|:.||.:||.||...|.::|:||:|||...|  |...
Mosquito   604 AKAVATECNLSFLSVQGPELLNMYVGQSEQNVREVFARARTASPCVLFLDELDSLAPNRGVSGDS 668

  Fly   596 HEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYV--SLPDEQTR 656
            .....|:.::.|.|.||:..:| |.:|.:|||||||..:|.|.||  ||.|.:||  |...|...
Mosquito   669 GGVMDRVVSQMLSEMDGISKDP-GQQIFILAATNRPDLIDPALLRPGRFDKLLYVGPSCTVEDKE 732

  Fly   657 ELLLNRLLQKQGSPLDTEALRRLAK-ITDGYSGSDLTALAKDAALEPIRE--------------L 706
            .:|  |.:..:....:|..||::|: :....:|:|:.::..:|.|..:|.              |
Mosquito   733 SVL--RAVTGRFRLAETLTLRKIAESLKQDMTGADMYSICSNAWLSAVRRTVKEAIAGDSIDEGL 795

  Fly   707 NVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSL 743
            |.:||         .:||.||..|:|:...|::|..:
Mosquito   796 NADQV---------IVTEDDFKESVKKFIPSISPADM 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	23/55 (42%)
		AAA	515..652	CDD:214640	65/142 (46%)
		AAA	519..650	CDD:278434	63/136 (46%)
		Vps4_C	<722..754	CDD:286426	8/22 (36%)
AgaP_AGAP001612	XP_321486.4	SpoVK	337..819	CDD:223540	139/486 (29%)
		P-loop_NTPase	339..461	CDD:304359	25/98 (26%)
		AAA	590..723	CDD:278434	62/133 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810