DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and AgaP_AGAP011967

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_320566.3	Gene:	AgaP_AGAP011967 / 1280704	VectorBaseID:	AGAP011967	Length:	782	Species:	Anopheles gambiae

Alignment Length:	594	Identity:	118/594 - (19%)
Similarity:	217/594 - (36%)	Gaps:	178/594 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 KEQQQSL----NHPSE--------LNREGDGQEQQ----LSNQPQRFRPIQPLEMAANRPGGGYS 218
            ||.|:..    :.|||        |:|:|...|..    ||::..:.:
Mosquito   280 KEYQKRTGRLPDFPSEEAGGSRHLLSRQGTESEMSRSSVLSSRESKLK----------------- 327

  Fly   219 PGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIA--VDCWSGRG 281
             |.|...||::|.......|.:.||.|             .:....:.|::.||.  .:.|.|:.
Mosquito   328 -GSGKEKLAQKKPGELSLEEGLDKAFK-------------PMQSSFLPEIKSGIEEYTEVWKGKD 378

  Fly   282 DVWDRAQRLHDKM---------QTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKT 337
            :..:..|..:|.|         :..|....|.     :..|:|::.:::|:..:..:...|..|
Mosquito   379 ESQNLRQTYYDDMIYEEKYADVEAELRRIVDE-----IMRQELELLQIALERDRGGKKLKKSSK- 437

  Fly   338 REPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSK 402
                           :.|.||            ..|:|     |:..:|.....:::|...|
Mosquito   438 ---------------KARRSG------------KKGKK-----KKDKDLTPDRTTESLFEEL--- 467

  Fly   403 TSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQ 467
            .:.|.:::.|                                       .||:.|..|......:
Mosquito   468 VTNGIIKKYP---------------------------------------ETPIKSYVGDLSYAAR 493

  Fly   468 LILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLL 532
            ..|:.             :..|| :|.:::..||| :..|.........|.||:.||.|:|||.|
Mosquito   494 SALNP-------------SPGDV-RQLIKQYCILP-LGSETIRNFGPCIKSLLIAGPKGSGKTSL 543

  Fly   533 ARAVATECSATFLNISAASLTSKYVGDGE--KLVRALFAVARHMQPSIIFIDEVDS-LLSERSSS 594
            ..|:.||..:...:||..::..||.|...  .|:..:..|:|.:|||:|:..:.:. .:.:...:
Mosquito   544 VHAICTETGSVLFDISPPNIVGKYPGKSGLIMLMHLISKVSRLLQPSVIYFGDAEKPFMKKIPKT 608

  Fly   595 EHEASRRLKTEFLVEFDGLPG-----NPDGDRIVVLAATNRPQELD-EAALRRFTKRVYVSLPDE 653
            :....:|||.:       ||.     .|: |||:::..::.|.|.| :..::.:.:.:|:..||.
Mosquito   609 DRTDPKRLKKD-------LPKLVKNIQPE-DRIMLIGTSDCPWEGDMKLMVQTYQRFIYIPRPDY 665

  Fly   654 QTRELLLNRLLQKQGS---PLDTEALRRLAKITDGYS-GSDLTALAKDAALEPIRELNVEQVKCL 714
            .........||.....   ..||.|   :|||:|||: ||.:..:.:....:.:.:|.|..:..|
Mosquito   666 GALSFAWKELLSHYSGVHRQFDTGA---MAKISDGYTIGSVVRCIREVITCKRMLQLRVHPLTHL 727

  Fly   715 D-ISAMRAI 722
            : |:|:.|:
Mosquito   728 ELINALSAL 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	15/88 (17%)
		P-loop_NTPase	482..>538	CDD:304359	18/55 (33%)
		AAA	515..652	CDD:214640	38/145 (26%)
		AAA	519..650	CDD:278434	37/139 (27%)
		Vps4_C	<722..754	CDD:286426	0/1 (0%)
AgaP_AGAP011967	XP_320566.3	SpoVK	<454..745	CDD:223540	76/351 (22%)
AgaP_AGAP011967	XP_320566.3	P-loop_NTPase	530..639	CDD:304359	33/116 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900