DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and AgaP_AGAP009625

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_318657.4	Gene:	AgaP_AGAP009625 / 1279001	VectorBaseID:	AGAP009625	Length:	395	Species:	Anopheles gambiae

Alignment Length:	355	Identity:	121/355 - (34%)
Similarity:	186/355 - (52%)	Gaps:	65/355 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 INNNGPSGSGASTPVVSVKGVEQKLVQLI-------LDE---------IVEGGAKVEWTDIAGQD 489
            |.|..||.......:...:.:.:||...:       |:|         :|.......|..|||.|
Mosquito    33 IRNLDPSNKSKKKAIEHAEEILRKLSPTMKKSALQNLNEYEMVIASHLVVPENITESWDSIAGLD 97

  Fly   490 VAKQALQEMVILPSVRPELFTG--LRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASL 552
            ...|.::|.::.|....::|.|  |..|.||:||:||||.||||:|:|.|.|....|:|:..|.|
Mosquito    98 DVCQEIKESLVFPVCHRDMFAGSALYQPPKGVLLYGPPGCGKTLIAKATAKEAGMRFINLDVAML 162

  Fly   553 TSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNP 617
            |.|:.|:.:||..|:|.:|..:||.||||||:||.|..|:||:|||:..:||:|::.:|||  |.
Mosquito   163 TDKWYGESQKLASAVFTLAVKIQPCIIFIDEIDSFLRARNSSDHEATAMMKTQFMMLWDGL--NT 225

  Fly   618 DGD-RIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAK 681
            :.| .|:|:.||||||:||:|.|||...:.::.||:|:.|..:|..:|..:....:.:.| :||:
Mosquito   226 ESDSTIIVMGATNRPQDLDKAILRRMPAQFHIGLPNEEQRHKILQLILANEKVAPEVDYL-QLAR 289

  Fly   682 ITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDI-SAMR------------------------- 720
            .|:|||||||..:.::|::..||::    :|..:| ||:|
Mosquito   290 KTNGYSGSDLKEVCRNASVHRIRKV----MKNKEIMSAVRAAANSKAQANGTAAGGSQLPNGFNG 350

  Fly   721 -------------AITEQDFHSSLKRIRRS 737
                         |||.:|...||:.:|.|
Mosquito   351 VTGQNGGLELGTPAITMEDLEESLRSMRHS 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	26/57 (46%)
		AAA	515..652	CDD:214640	69/137 (50%)
		AAA	519..650	CDD:278434	65/131 (50%)
		Vps4_C	<722..754	CDD:286426	7/16 (44%)
AgaP_AGAP009625	XP_318657.4	AAA	125..263	CDD:214640	70/139 (50%)
AgaP_AGAP009625	XP_318657.4	AAA	129..259	CDD:278434	65/131 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810