DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and AgaP_AGAP005630

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_315644.3	Gene:	AgaP_AGAP005630 / 1276315	VectorBaseID:	AGAP005630	Length:	804	Species:	Anopheles gambiae

Alignment Length:	715	Identity:	176/715 - (24%)
Similarity:	297/715 - (41%)	Gaps:	172/715 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 VHKQNLYVVSFPIIFLFNVLRSLIYQL-------FCIFRYLYGASTKVIY---RPHRRDCNIEIV 164
            :||.:.::|.       ..:|::.:::       :||.     |...||:   .|.:|:
Mosquito   143 IHKDDTFIVR-------GGMRAVEFKVVAADPEPYCIV-----APETVIHCEGNPIKRE------ 189

  Fly   165 VQNSSKEQQQSLNHPSELNREGDGQEQQLS----------NQPQRFRPIQPLEMAANRPGGGY-- 217
                  |::::||...  ..:..|..:||:          ..|..|:.|      ..:|..|.
Mosquito   190 ------EEEETLNAVG--YDDIGGCRKQLAQIKEMVELPLRHPSLFKAI------GVKPPRGILM 240

  Fly   218 --SPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELE----------- 269
              .||.|..|:|:...:...||.::....:|..:..|..|..:   ||..:|.|
Mosquito   241 YGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNL---RKAFEEAEKNSPAIIFIDE 302

  Fly   270 -DGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSK 333
             |.||           .:.::.|.::                 |:.:..|.|:|.:..|
Mosquito   303 IDAIA-----------PKREKTHGEV-----------------ERRIVSQLLTLMDGMK------ 333

  Fly   334 PQKTREPMLAGMTNEPMKL--RVRSSGYGPKATTSAQPTASGR--KLTIGSKRPVNLA------- 387
              |:...::...||.|..:  .:|..|...:......|.|:||  .|.|.:|. :.||
Mosquito   334 --KSSHVIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVLRIHTKN-MKLADDVDLEQ 395

  Fly   388 -VANKSQTLPRNLGSKTSVGAVQRQPAK---TAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSG 448
             .|.....:..:|.|..|..|:|:...|   .......:..:..:......:..|..:..:.||.
Mosquito   396 IAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDQIDAEVLNSLAVSMENFRYAMTKSSPSA 460

  Fly   449 SGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFT--G 511
                                 |.|.|.......||||.|.:..|:.|||:|..|...|:.|.  |
Mosquito   461 ---------------------LRETVVEVPNTTWTDIGGLENVKRELQELVQYPVEHPDKFLKFG 504

  Fly   512 LRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQP 576
            :: |::|:|.:||||.||||||:|:|.||.|.|:::....|.:.:.|:.|..||.:|..||...|
Mosquito   505 MQ-PSRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSASP 568

  Fly   577 SIIFIDEVDSLLSERSSSEHE---ASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAA 638
            .::|.||:||:...|..:..:   |:.|:..:.|.|.||:....:   :.::.|||||..:|.|.
Mosquito   569 CVLFFDELDSIAKSRGGNVGDAGGAADRVINQILTEMDGMGAKKN---VFIIGATNRPDIIDPAI 630

  Fly   639 LR--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEA-LRRLAKITDGYSGSDLTALAKDAAL 700
            ||  |..:.:|:.||||::||.:|...|:|  ||:..:. |..:||:|.|:||:|||.:.:.|..
Mosquito   631 LRPGRLDQLIYIPLPDEKSREAILRANLRK--SPVAEDVDLNYVAKVTQGFSGADLTEICQRACK 693

  Fly   701 EPIR-----ELNVEQVKCLDISAMRAITEQD---------FHSSLKRIRRSVAPQSLNSYEKWSQ 751
            ..||     |:..|:.:....:|...:.|:|         |..::|..||||:...:..||.::|
Mosquito   694 LAIRQAIEAEIRRERDRAASQNAAMDMDEEDPVPEITRDHFEEAMKFARRSVSDNDIRKYEMFAQ 758

Fly 752 751
Mosquito 759 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	13/89 (15%)
		P-loop_NTPase	482..>538	CDD:304359	28/57 (49%)
		AAA	515..652	CDD:214640	52/141 (37%)
		AAA	519..650	CDD:278434	49/135 (36%)
		Vps4_C	<722..754	CDD:286426	11/39 (28%)
AgaP_AGAP005630	XP_315644.3	CDC48	22..762	CDD:273521	176/715 (25%)
		CDC48_N	22..104	CDD:280513
		CDC48_2	128..188	CDD:215011	10/56 (18%)
		AAA	238..367	CDD:278434	29/167 (17%)
		AAA	511..644	CDD:278434	49/135 (36%)
		Vps4_C	<718..758	CDD:286426	10/39 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810