DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and AgaP_AGAP000625

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_310453.2	Gene:	AgaP_AGAP000625 / 1271692	VectorBaseID:	AGAP000625	Length:	441	Species:	Anopheles gambiae

Alignment Length:	560	Identity:	168/560 - (30%)
Similarity:	249/560 - (44%)	Gaps:	168/560 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 RRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNL 298
            ::|.:.::||.: ::.|:.::| |:.||..|::.....|.   :..:||
Mosquito     8 QKAIDIVTKATE-EDRNKNYEE-ALRLYEHGVEYFLHAIK---YEAQGD---------------- 51

  Fly   299 SMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKA 363
             .|:|.:....       .|.|...||.||
Mosquito    52 -KAKDSIRAKC-------FQYLDRAEKLKE----------------------------------- 73

  Fly   364 TTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSS 428
                       .|..|.|:||                 |...||.:...:|
Mosquito    74 -----------YLKKGKKKPV-----------------KDGDGAAKDDKSK-------------- 96

  Fly   429 GRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILD-EIVEGGAKVEWTDIAGQDVAK 492
                          .|..|.|.:..|       |:|.:|..|: .||.....|:|:|:||.:.||
Mosquito    97 --------------GNDSSDSDSDDP-------EKKKLQAKLEGAIVVEKPHVKWSDVAGLEGAK 140

  Fly   493 QALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATEC-SATFLNISAASLTSKY 556
            .||:|.||||...|.||||.|.|.||:|||||||.||:.||:|||||. ::||.::|::.|.||:
Mosquito   141 TALKEAVILPIKFPHLFTGKRMPWKGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLVSKW 205

  Fly   557 VGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDR 621
            :|:.||||:.||.:||..:|||:||||||||.|.||.:|.|::||:||||||:..|:  ..|.|.
Mosquito   206 LGESEKLVKNLFELARAHKPSIVFIDEVDSLCSARSDNESESARRIKTEFLVQMQGV--GSDNDG 268

  Fly   622 IVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGY 686
            ::||.|||.|..||.|..|||.||:|:.||||..|.::....|......|..:.||.||..|||:
Mosquito   269 VLVLGATNTPWILDSAIRRRFEKRIYIPLPDEHARLVMFKIHLGNTAHTLTEDNLRTLASKTDGF 333

  Fly   687 SGSDLTALAKDAALEPIRELNVEQ---------------------VKC------------LDISA 718
            ||||::.:.:||.::|:|::....                     |.|            :|:..
Mosquito   334 SGSDISIVVRDALMQPVRKVQTATHFKKVSGPSPVDKTTICDDLLVPCSPGDPGAIEMTWVDLPG 398

  Fly   719 MR----AITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            .:    .:|..|...||...:.:|....:...:|:::|:|
Mosquito   399 DKLFEPPVTMNDMLKSLASTKPTVNEDDMKKLDKFTEDFG 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	14/73 (19%)
		P-loop_NTPase	482..>538	CDD:304359	35/55 (64%)
		AAA	515..652	CDD:214640	77/137 (56%)
		AAA	519..650	CDD:278434	73/131 (56%)
		Vps4_C	<722..754	CDD:286426	7/31 (23%)
AgaP_AGAP000625	XP_310453.2	MIT_VPS4	5..69	CDD:239141	16/89 (18%)
		P-loop_NTPase	130..>186	CDD:304359	35/55 (64%)
		AAA	163..299	CDD:214640	77/137 (56%)
		AAA	167..297	CDD:278434	73/131 (56%)
		Vps4_C	378..438	CDD:286426	10/59 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D59575at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920