DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and AgaP_AGAP010924

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_309769.4	Gene:	AgaP_AGAP010924 / 1271027	VectorBaseID:	AGAP010924	Length:	1031	Species:	Anopheles gambiae

Alignment Length:	723	Identity:	163/723 - (22%)
Similarity:	271/723 - (37%)	Gaps:	179/723 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 KVIYRPHRRDCNI-------------EIVVQNSSKEQQQSLNHPSELNREGDGQEQQLSNQPQRF 200
            ||..:|.|...||             .|:.::..::.:|.:.|.|:::       ..|.||.|.|
Mosquito   342 KVTLKPIRNALNIVDRIELLPATKVAPIIEEDIVEKFKQFVLHNSKIH-------ALLLNQEQLF 399

  Fly   201 R--------PIQPLEM------------------AANRPGGGYSPGPGDPLLAKQKHHHRRAFEY 239
            :        .:||..:                  ...:|..|||...|    :|:|
Mosquito   400 KLPEYYLTLKLQPPALKYCLINSTILRHSKICCTGEVKPVAGYSDVDG----SKKK--------- 451

  Fly   240 ISKALKIDEENEGHKELAIELYRKGIKELEDG--------------------IAVDCWSGRGDVW 284
             ..|||..|..|..|.:.||...:.::|..|.                    ||....|||..|.
Mosquito   452 -PAALKDAESVEECKLVKIEKIERIVEECTDRLKYALCLDARCKVPQQCNMFIAGSSQSGRKTVC 515

  Fly   285 DR-AQRLHD---------------KMQTNLSMARDRLHFLAL----REQDLQMQRLSLKEKQKEE 329
            |. .:||.:               |.:...|:.:|..|.|.|    ....|.|..|.:...|..:
Mosquito   516 DNILKRLAEVPFYCFSTTFDCAKHKGRKPDSIQKDLRHALYLCMFHSPAVLFMDGLDVLAHQPGD 580

  Fly   330 AQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQT 394
             |:.|.......::.|..:.::   ..:|..|.|..::..::|.....:.|.|..:|  ..:...
Mosquito   581 -QNTPDAEYHNKVSDMIRKQIE---EFTGNNPIAVIASISSSSNLNRRLHSSRGYHL--FQQHVK 639

  Fly   395 LPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGAST------ 453
            ||.          :.:...:.|.....|:||....|....:|..     |...|....:
Mosquito   640 LPN----------LDKADREAALKSLFVQRQCKLDRRIDWKRLA-----NQTEGYAIGSLVQLVD 689

  Fly   454 -------------PVVSVKGVEQKL--------------VQLILDEIVEGGAKVEWTDIAGQDVA 491
                         |.|:...|.:.|              .|...||:.|...:|....:.|.:.|
Mosquito   690 RAVFYAYKQDGKFPFVTEAMVSEALDVTNRYCLVGIENHKQQATDELEEEDDEVPGDKVPGLEGA 754

  Fly   492 KQALQEMVILPSVRPELF--TGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTS 554
            .:..||:::.|:..|::|  :.||..| |:|||||||.|||.|...:|...:...:::....|.:
Mosquito   755 IEVFQEVLMWPTRFPKIFEASPLRNQA-GILLFGPPGTGKTYLVSKLAKTWNLRMISVKGPELLA 818

  Fly   555 KYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDG 619
            ||:|..|:.||.||..||..:|.::|.||.|||...|.......:.|:..:.|.|.||:.|.
Mosquito   819 KYIGQSEENVRNLFDRARSAKPCVLFFDEFDSLAPRRGHDSTGVTDRVVNQLLTELDGVEGL--- 880

  Fly   620 DRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTR-ELLLNRLLQKQGSPLDTEA-LRRLA 680
            ..:.|:.||:||:.||.|.||  |..:.|..:||....| |:..|   ..:...||.:. ||..|
Mosquito   881 QGVTVIGATSRPELLDPALLRSGRIDRLVECTLPGVTARLEIFSN---HSKSLTLDKDVDLREFA 942

  Fly   681 KITDGYSGSDLTALAKDAALEPIRELNVEQVKCLD-----ISAMRAITEQDFHSSLKRIRRSVAP 740
            ..::.|:|:|:.::...|.:..::|       ||.     :.....::::....:....|.|::|
Mosquito   943 VKSEYYTGADIRSILTTANMLAVQE-------CLSNDPEKVPEQITVSQRHLAEAFSSTRPSLSP 1000

  Fly   741 QSLNSYEK 748
            :.:..|.:
Mosquito  1001 RDIAKYRE 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	24/113 (21%)
		P-loop_NTPase	482..>538	CDD:304359	22/57 (39%)
		AAA	515..652	CDD:214640	52/138 (38%)
		AAA	519..650	CDD:278434	49/132 (37%)
		Vps4_C	<722..754	CDD:286426	4/27 (15%)
AgaP_AGAP010924	XP_309769.4	PEX-1N	92..167	CDD:286361
		AAA	783..913	CDD:278434	49/132 (37%)
		AAA	783..910	CDD:214640	48/129 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810