DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and AgaP_AGAP012684

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_307148.3	Gene:	AgaP_AGAP012684 / 1268587	VectorBaseID:	AGAP012684	Length:	471	Species:	Anopheles gambiae

Alignment Length:	337	Identity:	96/337 - (28%)
Similarity:	154/337 - (45%)	Gaps:	67/337 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 NNNGP-------SGSGASTPVVSVKGVEQKLVQLI------LDEIVEGGAKVEW----TDIAGQD 489
            :.|||       .|...:..||:.:..|...:.|:      :..:.:.....:|    ..|.|.|
Mosquito   140 SGNGPVEPKRVNFGRLLANTVVTFEKAESSGLNLVGRSKGRVTAVRQSIINPDWDFGRMGIGGLD 204

  Fly   490 -----VAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNI-S 548
                 :.::|....|..|.|..:|  |.: ..||:||:||||.||||:||.:.|..:|....| :
Mosquito   205 REFNAIFRRAFASRVFPPEVVEQL--GCK-HVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVN 266

  Fly   549 AASLTSKYVGDGEKLVRALFAVA----RHMQPS----IIFIDEVDSLLSER-----SSSEHEASR 600
            ...:..||||:.|..||.|||.|    :.:.|:    ||..||:|::...|     :|..|:.
Mosquito   267 GPQILDKYVGESEANVRRLFADAEEEEKRLGPASGLHIIIFDEIDAICKARGTVGGNSGVHDT-- 329

  Fly   601 RLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLN-- 661
             :..:.|.:.||:   ...:.|:|:..|||...:|||.||  |...::.:|||:|:.|..:||
Mosquito   330 -VVNQLLAKIDGV---EQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEEGRVQILNIH 390

  Fly   662 ----RLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIREL-----NVEQVKCLDIS 717
                :..:|....:|   ||.|.:.|..:||::|..|.:.|....:..|     .||    :|.:
Mosquito   391 TRRMKEFKKLAPDVD---LRELGQKTKNFSGAELEGLVRAAQSTAMNRLIKAASKVE----VDPA 448

  Fly   718 AMR--AITEQDF 727
            ||.  .:|.:||
Mosquito   449 AMEKLMVTREDF 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	24/64 (38%)
		AAA	515..652	CDD:214640	53/152 (35%)
		AAA	519..650	CDD:278434	49/146 (34%)
		Vps4_C	<722..754	CDD:286426	3/6 (50%)
AgaP_AGAP012684	XP_307148.3	CDC48_N	<10..53	CDD:215012
		CDC48_2	81..>126	CDD:215011
		AAA	234..379	CDD:214640	53/150 (35%)
		AAA	236..377	CDD:278434	49/146 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810