DRSC/TRiP Functional Genomics Resources

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Protein Alignment spas and Vcp

DIOPT Version :10

Sequence 1:NP_651206.3 Gene:spas / 42846 FlyBaseID:FBgn0039141 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_446316.1 Gene:Vcp / 116643 RGDID:621595 Length:806 Species:Rattus norvegicus


Alignment Length:648 Identity:167/648 - (25%)
Similarity:280/648 - (43%) Gaps:145/648 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   170 KEQQQSLNHPSELNREG-DGQEQQLS----------NQPQRFRPIQPLEMAANRPGGGY----SP 219
            :::::|||   |:..:. .|..:||:          ..|..|:.|      ..:|..|.    .|
  Rat   192 EDEEESLN---EVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAI------GVKPPRGILLYGPP 247

  Fly   220 GPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELE------------DGI 272
            |.|..|:|:...:...||.::....:|..:..|..|..:   ||..:|.|            |.|
  Rat   248 GTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNL---RKAFEEAEKNAPAIIFIDELDAI 309

  Fly   273 AVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKT 337
            |           .:.::.|.::                 |:.:..|.|:|.:..|:.|       
  Rat   310 A-----------PKREKTHGEV-----------------ERRIVSQLLTLMDGLKQRA------- 339

  Fly   338 REPMLAGMTNEPMKL--RVRSSGYGPKATTSAQPTASGRK--LTIGSKRPVNLA-------VANK 391
             ..::...||.|..:  .:|..|...:......|.|:||.  |.|.:|. :.||       |||:
  Rat   340 -HVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKN-MKLADDVDLEQVANE 402

  Fly   392 SQTLPRNLG-------SKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGS 449
            :.   .::|       |:.::.|::::..........:..:..:.........|..::.:.||. 
  Rat   403 TH---GHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSA- 463

  Fly   450 GASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFT--GL 512
                                |.|.|....:|.|.||.|.:..|:.|||:|..|...|:.|.  |:
  Rat   464 --------------------LRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGM 508

  Fly   513 RAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPS 577
             .|:||:|.:||||.||||||:|:|.||.|.|::|....|.:.:.|:.|..||.:|..||...|.
  Rat   509 -TPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPC 572

  Fly   578 IIFIDEVDSLLSERSSSEHE---ASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAAL 639
            ::|.||:||:...|..:..:   |:.|:..:.|.|.||:....:   :.::.|||||..:|.|.|
  Rat   573 VLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKN---VFIIGATNRPDIIDPAIL 634

  Fly   640 R--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEP 702
            |  |..:.:|:.||||::|..:|...|:|.....|.: |..|||:|:|:||:|||.:.:.|....
  Rat   635 RPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVD-LEFLAKMTNGFSGADLTEICQRACKLA 698

  Fly   703 IR-----ELNVEQVKCLDISAMRAITEQD---------FHSSLKRIRRSVAPQSLNSYEKWSQ 751
            ||     |:..|:.:..:.|||. :.|.|         |..:::..||||:...:..||.::|
  Rat   699 IRESIESEIRRERERQTNPSAME-VEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQ 760

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spasNP_651206.3 MIT_spastin 230..308 CDD:239142 13/89 (15%)
RecA-like_spastin 484..648 CDD:410932 64/170 (38%)
AAA_lid_3 676..727 CDD:465537 21/64 (33%)
Vps4_C <722..754 CDD:462762 10/39 (26%)
VcpNP_446316.1 CDC48 25..764 CDD:273521 167/648 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 708..727 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 768..806
Interaction with UBXN6. /evidence=ECO:0000250 797..806
PIM motif. /evidence=ECO:0000250|UniProtKB:P55072 802..806
Blue background indicates that the domain is not in the aligned region.

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