Protein Alignment spas and KATNA1

DIOPT Version :10

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_008975.1
• Gene: KATNA1 / 11104
• HGNCID: 6216
• Length: 491
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 182/550 - (33%)
• Similarity: 268/550 - (48%)
• Gaps: 101/550 - (18%)

  Fly   240 ISKALKIDEENE--GHKELAIELYR-------KGIKELEDGIAVDCWSGRGDVWD----RAQRLH 291
            ||:.:|:..|..  |:.:.|:..|:       |.:..::|......|.   .||.    .|:.:.
Human     6 ISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQ---QVWQEINVEAKHVK 67

  Fly   292 DKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRV-- 354
            |.|:|..|...|                            |.|.|..:..|.....|...:.|
Human    68 DIMKTLESFKLD----------------------------STPLKAAQHDLPASEGEVWSMPVPV 104

  Fly   355 -RSSGYGPKATTSAQ---PTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKT 415
             |....||:...|:|   |.:.|                |:..|..|          |.|..|:.
Human   105 ERRPSPGPRKRQSSQYSDPKSHG----------------NRPSTTVR----------VHRSSAQN 143

  Fly   416 AATP--PAVR----RQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIV 474
            ....  .|||    ::.:.||.   :::::|.....|     .|......|.::.||:.:..:|:
Human   144 VHNDRGKAVRCREKKEQNKGRE---EKNKSPAAVTEP-----ETNKFDSTGYDKDLVEALERDII 200

  Fly   475 EGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATE 539
            .....|.|.|||....||:.|:|.|:||...||.|.|:|.|.||:|:.||||.||||||:|||||
Human   201 SQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATE 265

  Fly   540 CSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSER-SSSEHEASRRLK 603
            |..||.|:|:::|||||.|:.|||||.||.:||...|:.|||||:||:.|.| :|.|||||||:|
Human   266 CKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVK 330

  Fly   604 TEFLVEFDGLPGNPDGD----RIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLL 664
            .|.||:.||:.|..:.|    .::||||||.|.::|||..||..||:|:.||..:.||.|| |:.
Human   331 AELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELL-RIS 394

  Fly   665 QKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRE----LNVEQVKCLDISAMR-AITE 724
            .::....|...|..:|:..:||||:|:|.:.:||:|..:|.    |..|:::.|....|. ..|.
Human   395 LRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTM 459

  Fly   725 QDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            :||..:||::.:||:...:..||||..::|
Human   460 EDFEMALKKVSKSVSAADIERYEKWIFEFG 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	18/80 (23%)
		RecA-like_spastin	484..648	CDD:410932	94/168 (56%)
		AAA_lid_3	676..727	CDD:465537	17/55 (31%)
		Vps4_C	<722..754	CDD:462762	11/31 (35%)
KATNA1	NP_008975.1	Interaction with microtubules	1..185		45/243 (19%)
		Interaction with dynein and NDEL1. /evidence=ECO:0000250	1..75		16/71 (23%)
		Interaction with KATNB1. /evidence=ECO:0000269|PubMed:10751153	1..29		6/22 (27%)
		Kp60-NTD	5..72	CDD:439297	15/68 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..185		24/131 (18%)
		RecA-like_KTNA1	210..379	CDD:410930	94/168 (56%)
		AAA_lid_3	403..447	CDD:465537	14/43 (33%)
		Vps4_C	<451..489	CDD:462762	12/37 (32%)