DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and YME1L1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_647473.1	Gene:	YME1L1 / 10730	HGNCID:	12843	Length:	773	Species:	Homo sapiens

Alignment Length:	279	Identity:	100/279 - (35%)
Similarity:	142/279 - (50%)	Gaps:	36/279 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   480 VEWTDIAGQDVAKQALQEMVILPSVRPELFT--GLRAPAKGLLLFGPPGNGKTLLARAVATECSA 542
            |.:..:.|.:.|||.|||:|.... .|:.||  |.:.| ||:||.||||.||||||||||.|...
Human   336 VTFEHVKGVEEAKQELQEVVEFLK-NPQKFTILGGKLP-KGILLVGPPGTGKTLLARAVAGEADV 398

  Fly   543 TFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSER-SSSEHEASRRLKTEF 606
            .|...|.:.....:||.|...:|.||..|:...|.:|||||:||:..:| .|..|..||:...:.
Human   399 PFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQL 463

  Fly   607 LVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTR-ELL---LNRLLQ 665
            |.|.||...|   :.::::.|||.|:.||.|.:|  ||..:|.|..||.:.| |:|   ||::
Human   464 LAEMDGFKPN---EGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKI-- 523

  Fly   666 KQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSS 730
            |....:|.|.   :|:.|.|:||::|..|...|||:..            :.....:|.::...|
Human   524 KFDQSVDPEI---IARGTVGFSGAELENLVNQAALKAA------------VDGKEMVTMKELEFS 573

  Fly   731 LKRI-----RRSVAPQSLN 744
            ..:|     ||||...:.|
Human   574 KDKILMGPERRSVEIDNKN 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	30/57 (53%)
		AAA	515..652	CDD:214640	59/139 (42%)
		AAA	519..650	CDD:278434	56/133 (42%)
		Vps4_C	<722..754	CDD:286426	8/28 (29%)
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	32/60 (53%)
		FtsH_fam	333..766	CDD:273520	100/279 (36%)
		AAA	375..506	CDD:278434	56/133 (42%)
		Peptidase_M41	586..764	CDD:279742	2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910