Protein Alignment spas and smc6.1

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_004918255.2
• Gene: smc6.1 / 100495634
• XenbaseID: XB-GENE-6071284
• Length: 1128
• Species: Xenopus tropicalis
• Alignment Length: 727
• Identity: 131/727 - (18%)
• Similarity: 245/727 - (33%)
• Gaps: 247/727 - (33%)

  Fly   150 VIYRPHRRDCNIEI-VVQNSSKEQQQSLNH---------PSELNREGDGQEQQLS-NQPQ----R 199
            |.|:....:|..:: :.:...:.:|:.|::         |..:..:.|.|:::.| |:.:    |
 Frog   344 VKYKQKIDECQGKVNIAEEKFRAKQEELDNITQEAVALKPQGIALKEDAQKKRKSYNESEVLYNR 408

  Fly   200 FR-PIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRK 263
            .| .::.||..|            |.|       |:|..|     ||...:|....|   ::.|:
 Frog   409 HRMELKRLERDA------------DQL-------HKRIEE-----LKKSADNASESE---KMARQ 446

  Fly   264 GIKELEDGIAVDCWSGRGDVWDRAQRLHDK-MQTNLSMARDRLHFLALREQDLQM--------QR 319
              ||:            ..:.||.:.|||| :.||..:.:.:......:|:.:::        ||
 Frog   447 --KEI------------AQIRDRMKALHDKEITTNQQIHQFQQAIEKYKEERIRIGNEERNVKQR 497

  Fly   320 LSLKEKQ-KEEAQSKPQKTRE-----PMLAGMTNEPMKL-RVRSSGYGPKATTSAQPTASGRKLT 377
            |...::| :|..:||..:.|.     |.|....:|..|| |.|....||
 Frog   498 LEQHKRQLRELHESKTDRLRRFGQNMPALLAAIDEAYKLGRFRKKPVGP---------------- 546

  Fly   378 IGS---KRPVNLAVA----------------NKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVR 423
            :|:   .:...||:|                ::.:.:.:|:.|
 Frog   547 LGACIHLKDQELALAVECCLKGLLFAFCCDNHQDERMLQNIMS---------------------- 589

  Fly   424 RQFSSGRNTPPQ-------------RSRTPINNNGPSGSGA---STPVVS-----VKGVEQKLVQ 467
            |::..||.  ||             ..|...:.|.|:...|   ..|||:     ::|||..|:
 Frog   590 REYPRGRR--PQIIVNEFRDQVYDVSRRATFHPNHPTVLTALEIDHPVVANCLIDMRGVETILI- 651

  Fly   468 LILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLL 532
                             |.|.|.|::.:|:.....:.| |.|||..........:........:|
 Frog   652 -----------------IKGTDEAREIMQKRAPPRNCR-EAFTGEGDQVYTNRYYSSDTRRAAIL 698

  Fly   533 ARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHE 597
            :|.|..|.|.....:      ..:.|...|..:.|.:|.:.       :.|.:.:|.:..:|:.:
 Frog   699 SRDVEAEISHLEKEL------RNFGGQMAKFQQRLHSVDKD-------VKENEDILRQYHNSKKQ 750

  Fly   598 ASRRLK--TEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLL 660
            ....|:  :|.:.|.:.:...|..|     .||     |:..|.....|...|....|.|:|.:.
 Frog   751 IQIDLRAFSERIAELENVEEQPSID-----IAT-----LEGEAEENLNKIELVKQEMELTKENMG 805

  Fly   661 N-RLLQKQGSPLDTEALRRLAKITDGYS--GSDLTALAKD------------------------- 697
            | :||.........|..|:::.:::...  ..||..:.::
 Frog   806 NLKLLLTMAESNYEEIKRKISSVSEVAEPVKEDLHRIDQEVENCKRHKKHYVDKLKEHLDRIQKR 870

  Fly   698 ----AALEPIRELNVEQVKC-----LDISAMRAITEQDFHSSLKRIRRSVAPQS---------LN 744
                |..|...|:.:.|.||     :::|.    |.:...:.:.|:|..:..:.         :.
 Frog   871 KEEVAGKEQELEVKISQAKCVCPERIEVSR----TARSLDTEITRLREKINSEEVLHGNREEIIK 931

  Fly   745 SYEKWSQDYGDI 756
            .|.:..:.|.|:
 Frog   932 QYHEAKERYQDV 943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	18/78 (23%)
		P-loop_NTPase	482..>538	CDD:304359	13/55 (24%)
		AAA	515..652	CDD:214640	23/138 (17%)
		AAA	519..650	CDD:278434	23/132 (17%)
		Vps4_C	<722..754	CDD:286426	4/40 (10%)
smc6.1	XP_004918255.2	Smc	87..1107	CDD:224117	131/727 (18%)
		ABC_SMC6_euk	<1015..1113	CDD:213243

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165166210
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930