Protein Alignment spas and fign

DIOPT Version :10

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_004917757.1
• Gene: fign / 100488151
• XenbaseID: XB-GENE-1011106
• Length: 783
• Species: Xenopus tropicalis
• Alignment Length: 793
• Identity: 199/793 - (25%)
• Similarity: 325/793 - (40%)
• Gaps: 166/793 - (20%)

  Fly    11 SSASSSSTKSPIKSSSGAGSSGGGLGGRQSTHRSSSASN---------VAAVVAGGSSAAGGGS- 65
            |.....|...|:.|:.....||...|.:..:....|:.|         ||.|:.  :|..|.||
 Frog   105 SGILDGSMDRPLLSNYTEVQSGLVNGRKNESEPWQSSLNSEGVYPMNCVADVIT--ASKGGVGSA 167

  Fly    66 ---SSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPIIFLFN 127
               |....|.|||| |.....:....:.:||.     .|:.....|.:..|. |...:...:|..
 Frog   168 IPPSDVSASIGSSP-GVASNLSEPSYSSSTCG-----SHTVPSLHSGLPSQE-YATGYNGSYLHT 225

  Fly   128 VLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQ 192
            ...|              .|...:..||....:...::|.......     ||.|....:|....
 Frog   226 SYSS--------------QSASALPSPHPSPLHSSGLLQPPPPPPP-----PSALVPGYNGTSSI 271

  Fly   193 LS-NQPQRFRPIQPLEMAANRPGGGYSPG----------PGDPLLAKQKHHHRRAFEYISKALKI 246
            .| |.|....|.|      :..|.|||||          .|.|............:.|.|..|..
 Frog   272 PSYNYPPASYPPQ------SAVGSGYSPGSAPPPSAYLPSGIPAPTPLPPTTVPGYSYQSHGLTP 330

  Fly   247 DEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALR 311
            ...:......|..|.||..          ..:|:||:        :....|.|..:.|
 Frog   331 IAPSVVSNNSASSLKRKAF----------YMAGQGDI--------ESSYGNYSYGQQR------- 370

  Fly   312 EQDLQMQRLSLKEKQKEEAQSKPQKTREPML----AGMTNEPMKLRVRSSGYGPKATTSAQPTAS 372
                                    .:..||.    :.:||..     |.:|:...|.|.
 Frog   371 ------------------------SSHSPMYRMPDSSITNSN-----RGNGFDRSAETG------ 400

  Fly   373 GRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRS 437
                        :||.....|.:|.:...|.:      ..:..|.|||:    :||.:|:....|
 Frog   401 ------------SLAFKPTKQLVPSDQQRKFN------NQSTRALTPPS----YSSTKNSRSSDS 443

  Fly   438 RTPINNNG--------------PSGSGASTPVVS-------VKGVEQKLVQLILDEIVEGGAKVE 481
            ....|::.              ..|.|..|...|       :|..:..|:.|:.:||:..|..|:
 Frog   444 FGKYNSSALNEHSDEHRLIPHTMQGPGLHTATSSNHSVDDQLKNTDSHLIDLVTNEIINQGHPVD 508

  Fly   482 WTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLN 546
            |.:|||.|:.|..::|.|:.|.:|.:.|:||.|..:.:|||||.|.|||||.|.:|::..|||..
 Frog   509 WDEIAGLDLVKAFIKEEVLWPVIRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFK 573

  Fly   547 ISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFD 611
            |||::|.:|::.:|||:|.|.|.|||..|||:||:.::|.|||.:.:.||....|::||||::.|
 Frog   574 ISASNLVTKWITEGEKIVHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPISRMRTEFLMQLD 638

  Fly   612 GLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEAL 676
            .:..:.: |:|||:.||::|:::||:..|.|.||:.:.|||...|..::.:||.:....|:.:.:
 Frog   639 TVLSSAE-DQIVVICATSKPEQIDESLRRYFMKRLLIPLPDSTARHQIIIQLLSQHNYCLNDKEV 702

  Fly   677 RRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQ 741
            ..|.:.|:|:||.|:..|.::|.:.|:..:....:..:..:.:|.:|.|||.:...:|:.|::.:
 Frog   703 ALLVQRTEGFSGLDVARLCQEAVVGPLHAIPPSDLSAIMPNQLRPVTYQDFENVFCKIQPSISQK 767

  Fly   742 SLNSYEKWSQDYG 754
            .|::|.:|::.:|
 Frog   768 ELDTYIEWNKMFG 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	13/77 (17%)
		RecA-like_spastin	484..648	CDD:410932	73/163 (45%)
		AAA_lid_3	676..727	CDD:465537	12/50 (24%)
		Vps4_C	<722..754	CDD:462762	9/31 (29%)
fign	XP_004917757.1	RecA-like_fidgetin	511..674	CDD:410931	73/163 (45%)
		AAA_lid_3	705..>732	CDD:465537	9/26 (35%)
		Vps4_C	<732..780	CDD:462762	10/47 (21%)