DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and spg7

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_002933705.2	Gene:	spg7 / 100485977	XenbaseID:	XB-GENE-6034036	Length:	768	Species:	Xenopus tropicalis

Alignment Length:	285	Identity:	99/285 - (34%)
Similarity:	149/285 - (52%)	Gaps:	36/285 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   473 IVEG--GAKVEWTDIAGQDVAKQALQEMV-ILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLAR 534
            ||:|  |..:.:.|:||...||..::|.| .|.|....|..|.:.| ||.||.||||.||||||:
Frog   270 IVDGKSGKGISFKDVAGMHEAKLEVKEFVDYLKSPDRYLQLGAKVP-KGALLLGPPGCGKTLLAK 333

  Fly   535 AVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSS-----S 594
            |||||....||.::.:.......|.|...||:||..||...|.|::|||:|::..:||:     |
Frog   334 AVATEAQVPFLAMAGSEFVEVIGGLGAARVRSLFKEARTRAPCIVYIDEIDAVGKKRSTNMSSFS 398

  Fly   595 EHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPD-EQTR 656
            ..|..:.| .:.|||.||:...   |.::|||:|||...||.|.:|  |..:.:::.||. ::.|
Frog   399 NTEEEQTL-NQLLVEMDGMGTT---DHVIVLASTNRADILDNALMRPGRLDRHIFIDLPTLQERR 459

  Fly   657 ELLLNRL----LQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDIS 717
            |:....|    |.:.||...    :|||::|.|:||:|:..:..:|||...||
Frog   460 EIFEQHLKSLKLTQPGSFYS----QRLAELTPGFSGADIANICNEAALHAARE------------ 508

  Fly   718 AMRAITEQDFHSSLKRIRRSVAPQS 742
            ..::|...:|..:::|:....|.:|
Frog   509 GYQSIDTFNFEYAVERVIAGTAKKS 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	28/56 (50%)
		AAA	515..652	CDD:214640	59/143 (41%)
		AAA	519..650	CDD:278434	55/137 (40%)
		Vps4_C	<722..754	CDD:286426	5/21 (24%)
spg7	XP_002933705.2	FtsH_ext	118..215	CDD:377663
spg7	XP_002933705.2	FtsH_fam	239..720	CDD:273520	99/285 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910