DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and fignl1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001096311.1	Gene:	fignl1 / 100124890	XenbaseID:	XB-GENE-1000359	Length:	656	Species:	Xenopus tropicalis

Alignment Length:	368	Identity:	161/368 - (43%)
Similarity:	237/368 - (64%)	Gaps:	11/368 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 ANKSQTLPRNL--GSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGA 451
            :|:.|..|..|  |:|.|:||.:.:.......||..|::       ..|.|...:...|.|...|
Frog   295 SNQPQRNPSPLYGGAKKSLGAARSRGLHGKFVPPVPRQE-------DVQDSNRKVYGQGNSEMNA 352

  Fly   452 STPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPA 516
            .:. ..:|.:|.|:::||:.||::.|..:.|.||||.:.||..::|:|:.|.:||::|||||.|.
Frog   353 PSD-ERLKNIEPKMIELIMSEIMDHGPPLNWDDIAGLEFAKTTIKEIVVWPMLRPDIFTGLRGPP 416

  Fly   517 KGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFI 581
            ||:|||||||.||||:.:.:|.:..|||.:|||:|||||:||:|||:|||||.|||..||::|||
Frog   417 KGILLFGPPGTGKTLIGKCIACQSGATFFSISASSLTSKWVGEGEKMVRALFTVARCHQPAVIFI 481

  Fly   582 DEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRV 646
            ||:|||||:|...|||:|||:||||||:.||...:.| |||:|:.|||||||:||||.||..||:
Frog   482 DEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATTSSD-DRILVVGATNRPQEIDEAARRRLVKRL 545

  Fly   647 YVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQV 711
            |:.||:...|:.::..|:.|:...|..:.:..:....||:||:|:|.|.::|||.|||.:.:..:
Frog   546 YIPLPEASARKQIVVSLMAKEHCSLAEQEVEAIVLQADGFSGADMTQLCREAALGPIRSIQLMDI 610

  Fly   712 KCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            ..:....:|.|...||.|:...:|.||:.:.|..||.|::.:|
Frog   611 STITPEQVRPIAYIDFQSAFLVVRPSVSQKDLELYENWNKTFG 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	31/55 (56%)
		AAA	515..652	CDD:214640	88/136 (65%)
		AAA	519..650	CDD:278434	84/130 (65%)
		Vps4_C	<722..754	CDD:286426	11/31 (35%)
fignl1	NP_001096311.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..354		17/65 (26%)
fignl1	NP_001096311.1	SpoVK	<356..650	CDD:223540	143/294 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920