DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Miro and RHOT2

DIOPT Version :9

Sequence 1:NP_001262895.1 Gene:Miro / 42845 FlyBaseID:FBgn0039140 Length:673 Species:Drosophila melanogaster
Sequence 2:XP_024306246.1 Gene:RHOT2 / 89941 HGNCID:21169 Length:790 Species:Homo sapiens


Alignment Length:827 Identity:314/827 - (37%)
Similarity:426/827 - (51%) Gaps:212/827 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RKNVRILLVGDAGVGKTSLILSLVSEEYPEEVPPRAEEITIPANVTPEQVPTSIVDFSAVEQSED 73
            |::|||||:|:|.|||||||||||.||:|||||||||||||||:||||:|||.|||:|..||:::
Human     2 RRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPPRAEEITIPADVTPEKVPTHIVDYSEAEQTDE 66

  Fly    74 ALAAEINKAHVVCIVYAVDDDDTLDRIT------------------------------------- 101
            .|..||:||:|||:||.|.::.|:::::                                     
Human    67 ELREEIHKANVVCVVYDVSEEATIEKVSPQCRPQQQRHSGRWWPRWTFTQPVASAIAHSILGSLT 131

  Fly   102 ----------------------------------------------------------------- 101
                                                                             
Human   132 WSCLTWSHPALSCDPTSPERVWGVPQSEPLRPAVLFLPQFPNPRGGTRRGPALGAALGLGPSDLG 196

  Fly   102 ---SHW------------------------------LPL-------------------------- 107
               |||                              |||                          
Human   197 VFGSHWGQTDEAAPAACLLPPALFLWPGLGPSVGLDLPLLLSPSQAHAPAGSHVPAGSLTSQPGF 261

  Fly   108 ---VRAKCNPSLDGEGDAEAEAEGDTQREPIRKPIVLVGNKIDLIEYSTMDSVLAIMEDYPEIES 169
               :|.|..|.::|         |.||..  |.||:|||||.||...|:|::||.||..:||||:
Human   262 AFQIRTKWIPLVNG---------GTTQGP--RVPIILVGNKSDLRSGSSMEAVLPIMSQFPEIET 315

  Fly   170 CVECSAKSLHNISEMFYYAQKAVLHPTSPLYMMEEQELTSACKKSLVRIFKICDIDGDNLLNDYE 234
            |||||||:|.||||:||||||||||||:|||..|.::|..||.::|.|||::.|.|.|..|:|.|
Human   316 CVECSAKNLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDLDQALSDEE 380

  Fly   235 LNLFQRRCFNTPLQPQILDEVKAVIQKNVPDGIYNDAVTLKGFLFLHCLFIQRGRNETTWAVLRR 299
            ||.||:.||..||.||.|::||.|:.:||..|:..|.:||.|||||:.|||||||:||||.:|||
Human   381 LNAFQKSCFGHPLAPQALEDVKTVVCRNVAGGVREDRLTLDGFLFLNTLFIQRGRHETTWTILRR 445

  Fly   300 FGYNDQLEMCQEYLRPPLKIPPGSSTELSHRGQQFLIAVFERYDRDGDGALSPEEHKMLFSTCPA 364
            |||:|.||:..:||.|.:.:|||.||||:|.|.||:..|||::|:|.||||||.|.:.|||..||
Human   446 FGYSDALELTADYLSPLIHVPPGCSTELNHLGYQFVQRVFEKHDQDRDGALSPVELQSLFSVFPA 510

  Fly   365 APWSYSTDIRKSCPINETTGWVTLHGWLCRWTLMTLIDVVKTMEYLAYLGFNVHENDSQLAAIHV 429
            |||  ..::.::  :....|.:.|||:||:|||:|.:||...:.:|.|||:.......|..||.|
Human   511 APW--GPELPRT--VRTEAGRLPLHGYLCQWTLVTYLDVRSCLGHLGYLGYPTLCEQDQAHAITV 571

  Fly   430 TRERRIDLAKRQSSRSVYKCHVIGPKGSGKTGMCRGFLVEDMHKLIGKEFKTNVVNCINSVQVYG 494
            |||:|:|..|.|:.|||..|.|:|.:|.||:...:.||...:.....:|.....  .|::|||.|
Human   572 TREKRLDQEKGQTQRSVLLCKVVGARGVGKSAFLQAFLGRGLGHQDTREQPPGY--AIDTVQVNG 634

  Fly   495 QEKHLILRDIDVRHALDPLQPQEVNCDVACLVYDSSNPRSFEYVARIYIKYYAESKIPVMIVGTK 559
            |||:|||.::.....|  ....:..||||||::|.|:|:||.:.|.:|..:|.:.:.|.:.|.:|
Human   635 QEKYLILCEVGTDGLL--ATSLDATCDVACLMFDGSDPKSFAHCASVYKHHYMDGQTPCLFVSSK 697

  Fly   560 CDMDERRQDYLMQPSEFCDKYKLLPPHLFSL---KTNKKELYTKLATMAAFPRFQAAWILFYKHR 621
            .|:.|........|:|||.|::|..|..||.   ......::|:||||||||....|        
Human   698 ADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAGPAEPSTTIFTQLATMAAFPHLVHA-------- 754

  Fly   622 LVQLWESAHLRQFGLMTEDPKLWLKAGLGV---AAATMLGFIVLKTI 665
                  ..|...|         ||:..|||   |.|.:|.|.:.:.:
Human   755 ------ELHPSSF---------WLRGLLGVVGAAVAAVLSFSLYRVL 786

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MiroNP_001262895.1 Miro1 10..195 CDD:206680 114/348 (33%)
RHO 14..195 CDD:197554 112/344 (33%)
EF_assoc_2 247..328 CDD:285547 47/80 (59%)
EF_assoc_1 367..437 CDD:285546 25/69 (36%)
Miro2 444..620 CDD:206679 62/178 (35%)
Ras 448..602 CDD:278499 50/156 (32%)
RHOT2XP_024306246.1 P-loop_NTPase 3..341 CDD:328724 114/348 (33%)
EF_assoc_2 392..477 CDD:312012 50/84 (60%)
EF_assoc_1 513..579 CDD:312011 25/69 (36%)
Miro2 585..761 CDD:206679 63/193 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 211 1.000 Domainoid score I2802
eggNOG 1 0.900 - - E2759_KOG1707
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 642 1.000 Inparanoid score I812
Isobase 1 0.950 - 0 Normalized mean entropy S1464
OMA 1 1.010 - - QHG55756
OrthoDB 1 1.010 - - D239599at33208
OrthoFinder 1 1.000 - - FOG0001617
OrthoInspector 1 1.000 - - otm41606
orthoMCL 1 0.900 - - OOG6_101658
Panther 1 1.100 - - LDO PTHR24072
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2129
SonicParanoid 1 1.000 - - X1026
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.820

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