DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Miro and RHO4

DIOPT Version :9

Sequence 1:	NP_001262895.1	Gene:	Miro / 42845	FlyBaseID:	FBgn0039140	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_012981.3	Gene:	RHO4 / 853929	SGDID:	S000001763	Length:	291	Species:	Saccharomyces cerevisiae

Alignment Length:	244	Identity:	63/244 - (25%)
Similarity:	98/244 - (40%)	Gaps:	50/244 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YTASQRKN------VRILLVGDAGVGKTSLILSLVSEEYPEEVPPRAEE--ITIPANVTPEQVPT 60
            |...:|.|      ::|::|||..||||.|::|.|...:|.:..|...|  :|.......:.:..
Yeast    59 YEQMKRTNKLPDYHLKIVVVGDGAVGKTCLLISYVQGTFPTDYIPTIFENYVTNIEGPNGQIIEL 123

  Fly    61 SIVDFSAVEQSEDALAAEINKAHVVCIVYAVDDDDTLDRITSHWLPLVRAKCNPSLDGEGDAEAE 125
            ::.|.:..|:...........|.|:.:.|:|....:|..:...|.|.|:..| ||
Yeast   124 ALWDTAGQEEYSRLRPLSYTNADVLMVCYSVGSKTSLKNVEDLWFPEVKHFC-PS---------- 177

  Fly   126 AEGDTQREPIRKPIVLVG---------NKIDLIEYSTMDSVLAIMEDYPEIESCVECSAKSLHNI 181
                       .||:|||         |..||:|.|:.:|:...:..:..|    :|||:...||
Yeast   178 -----------TPIMLVGLKSDLYEADNLSDLVEPSSAESLAKRLGAFAHI----QCSARLKENI 227

  Fly   182 SEMFYYAQKAVLHPTSPLYMMEEQELTSACKKSLVRIFKICDID---GD 227
            .|:|..|...:|  :..||  ..:|.|...|....|.....|||   ||
Yeast   228 DEVFETAIHTLL--SDSLY--APREPTHTIKNPFKRNTTRSDIDSSTGD 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Miro	NP_001262895.1	Miro1	10..195	CDD:206680	50/201 (25%)
		RHO	14..195	CDD:197554	49/191 (26%)
		EF_assoc_2	247..328	CDD:285547
		EF_assoc_1	367..437	CDD:285546
		Miro2	444..620	CDD:206679
		Ras	448..602	CDD:278499
RHO4	NP_012981.3	Rho4_like	70..248	CDD:206704	51/207 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1464
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950