Protein Alignment Miro and MIRO2

DIOPT Version :9

• Sequence 1: NP_001262895.1
• Gene: Miro / 42845
• FlyBaseID: FBgn0039140
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_567139.1
• Gene: MIRO2 / 825490
• AraportID: AT3G63150
• Length: 643
• Species: Arabidopsis thaliana
• Alignment Length: 692
• Identity: 247/692 - (35%)
• Similarity: 368/692 - (53%)
• Gaps: 80/692 - (11%)

  Fly     2 GQYTASQRKNVRILLVGDAGVGKTSLILSLVSEEYPEEVPPRAEEITIPANVTPEQVPTSIVDFS 66
            |:.:|..|.::|:.:.||.|.||:|||.::.||.:|:.||.....||:||:..|:.:|.:|||..
plant     5 GKSSAGGRTSLRVAVAGDKGTGKSSLISAVASETFPDNVPRVLPPITLPADAFPDYIPITIVDTP 69

  Fly    67 AVEQSEDALAAEINKAHVVCIVYAVDDDDTLDRITSHWLPLVRAKCNPSLDGEGDAEAEAEGDTQ 131
            :...:...|..|..||.||.:.||.|...||||::|:|||.:|
plant    70 SSIDNRIKLIEEFRKADVVLLTYACDQPSTLDRLSSYWLPELR---------------------- 112

  Fly   132 REPIRKPIVLVGNKIDLIEY---STMDSVLA-IMEDYPEIESCVECSAKSLHNISEMFYYAQKAV 192
            |..|:.|:::||.|:||.:.   :.::.::: ||::|.|||:|:||||.:|..:.::||:|.|||
plant   113 RLEIKAPVIVVGCKLDLRDERSPARLEDIMSPIMKEYREIETCIECSALTLIQVPDVFYFASKAV 177

  Fly   193 LHPTSPLYMMEEQELTSACKKSLVRIFKICDIDGDNLLNDYELNLFQRRCFNTPLQPQILDEVKA 257
            ||||.||:..|:|.|....::::.|||.:||.|.|..|||.|||.||..||..||.|..|..||.
plant   178 LHPTFPLFDQEKQCLKPRLRRAVQRIFNLCDHDLDGALNDAELNDFQVNCFGAPLDPVELMGVKK 242

  Fly   258 VIQKNVPDGIYNDAVTLKGFLFLHCLFIQRGRNETTWAVLRRFGYNDQLEMCQEYLRPPLKIPPG 322
            |:|:..|||:.:..:||.|||||..|||:|||.||.||:||:.||||.||:..|.|..|.|..|.
plant   243 VVQERQPDGVTDLGLTLPGFLFLFSLFIERGRPETAWAILRKCGYNDSLELHAELLPVPAKQSPD 307

  Fly   323 SSTELSHRGQQFLIAVFERYDRDGDGALSPEEHKMLFSTCPAAPWSYSTDIRKSCPINETTGWVT 387
            .|.||::....||..:|:.||.|.||||.|.|...||.|.|.:||  ..|..|........|.:|
plant   308 QSIELTNEAMDFLSGIFQLYDLDNDGALQPAELDDLFQTAPDSPW--LEDPYKEAAEKTPGGSLT 370

  Fly   388 LHGWLCRWTLMTLIDVVKTMEYLAYLGFNVHENDSQLAAIHVTRERRIDLAKRQSSRSVYKCHVI 452
            ::|:|..|.||||:|..|::..|.|:|:. |:..|..:   |||:|.:|..|:::.|:|::|.|.
plant   371 INGFLSEWALMTLLDPRKSLANLTYIGYG-HDPASTFS---VTRKRSVDRKKQRTERNVFQCFVF 431

  Fly   453 GPKGSGKTGMCRGFL---VEDMHK-LIGKEFKTNVVNCINSVQVYGQEKHLILRDIDVRHALDPL 513
            |||.|||:.:...||   ..:.:| .:|:.:..||::     |..|.:|.||||:|........|
plant   432 GPKKSGKSALLDSFLGRKFSNSYKATMGERYAANVID-----QPGGSKKTLILREIPEDRVKKFL 491

  Fly   514 QPQE--VNCDVACLVYDSSNPRSFEYVARIYIKYYAESK-----IPVMIVGTKCDMDERRQDYLM 571
            ..:|  ..||||.:|||||:..|:.....|.::.....:     .|.::|..|.|:|    .|.|
plant   492 TNKESLAACDVAVVVYDSSDVYSWRKAREILMEVARRGEERGYGTPCLLVAAKDDLD----PYPM 552

  Fly   572 QPSE---FCDKYKLLPPHLFSLKTNK-KELYTKLATMAAFPRFQAAWILFYKHRLVQLWESA--- 629
            ...|   .|.:..:..|...|:|..: ..|::::.:.|..|           |..:...||.
plant   553 SVQESDRVCMELGIDIPVSLSMKLGEPNSLFSRIVSTAENP-----------HMSIPETESGRRS 606

  Fly   630 -HLRQFGLMTEDPKLWLKAGLGVAAATMLGFIVLKTISAAGA 670
             ::||   :.....|::..|      |.:||..|....|..|
plant   607 RNIRQ---LVNSSLLFVSVG------TAVGFAGLAAYRAYSA 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Miro	NP_001262895.1	Miro1	10..195	CDD:206680	68/188 (36%)
		RHO	14..195	CDD:197554	67/184 (36%)
		EF_assoc_2	247..328	CDD:285547	42/80 (53%)
		EF_assoc_1	367..437	CDD:285546	23/69 (33%)
		Miro2	444..620	CDD:206679	52/190 (27%)
		Ras	448..602	CDD:278499	48/168 (29%)
MIRO2	NP_567139.1	Miro1	13..180	CDD:206680	68/188 (36%)
		EF_assoc_2	230..316	CDD:369829	44/85 (52%)
		EF_assoc_1	352..417	CDD:369828	24/70 (34%)
		Miro2	422..604	CDD:206679	55/201 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	120	1.000	Domainoid score	I1885
eggNOG	1	0.900	-	-		E2759_KOG1707
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56803
Inparanoid	1	1.050	381	1.000	Inparanoid score	I532
OMA	1	1.010	-	-		QHG55756
OrthoDB	1	1.010	-	-		D538388at2759
OrthoFinder	1	1.000	-	-		FOG0001617
OrthoInspector	1	1.000	-	-		otm3306
orthoMCL	1	0.900	-	-		OOG6_101658
Panther	1	1.100	-	-	O	PTHR24072
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1026
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840