Protein Alignment Miro and Rhot1

DIOPT Version :9

• Sequence 1: NP_001262895.1
• Gene: Miro / 42845
• FlyBaseID: FBgn0039140
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: XP_006533949.1
• Gene: Rhot1 / 59040
• MGIID: 1926078
• Length: 752
• Species: Mus musculus
• Alignment Length: 609
• Identity: 318/609 - (52%)
• Similarity: 433/609 - (71%)
• Gaps: 33/609 - (5%)

  Fly     6 ASQRKNVRILLVGDAGVGKTSLILSLVSEEYPEEVPPRAEEITIPANVTPEQVPTSIVDFSAVEQ 70
            :..:|:|||||||:..|||||||:||||||:|||||||||||||||:||||:|||.|||:|..||
Mouse    12 SDMKKDVRILLVGEPRVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSEAEQ 76

  Fly    71 SEDALAAEINKAHVVCIVYAVDDDDTLDRITSHWLPLVRAKCNPSLDGEGDAEAEAEGDTQREPI 135
            |::.|..||::|:|:||||||::..::|::||.|:||:..:                  |.::.
Mouse    77 SDEQLHQEISQANVICIVYAVNNKHSIDKVTSRWIPLINER------------------TDKDS- 122

  Fly   136 RKPIVLVGNKIDLIEYSTMDSVLAIMEDYPEIESCVECSAKSLHNISEMFYYAQKAVLHPTSPLY 200
            |.|::|||||.||:|||:|:::|.||..|.|||:|||||||:|.||||:||||||||||||.|||
Mouse   123 RLPLILVGNKSDLVEYSSMETILPIMNQYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLY 187

  Fly   201 MMEEQELTSACKKSLVRIFKICDIDGDNLLNDYELNLFQRRCFNTPLQPQILDEVKAVIQKNVPD 265
            ..||:|:..||.|:|.|||||.|.|.|..|||.|||.|||.||||||.||.|::||.|::|::.|
Mouse   188 CPEEKEMKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVKNVVRKHLSD 252

  Fly   266 GIYNDAVTLKGFLFLHCLFIQRGRNETTWAVLRRFGYNDQLEMCQEYLRPPLKIPPGSSTELSHR 330
            |:.:..:||:||||||.|||||||:||||.|||||||:|.|::..|||.|.|||||..:|||:|.
Mouse   253 GVADSGLTLRGFLFLHTLFIQRGRHETTWTVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTELNHH 317

  Fly   331 GQQFLIAVFERYDRDGDGALSPEEHKMLFSTCPAAPWSYSTDIRKSCPINETTGWVTLHGWLCRW 395
            ...||.:.|:::|.|.|.||||:|.|.||...|..||  ..|:..:...|| .||:|..|:|.:|
Mouse   318 AYLFLQSTFDKHDLDRDCALSPDELKDLFQVFPYIPW--GPDVNNTVCTNE-RGWITYQGFLSQW 379

  Fly   396 TLMTLIDVVKTMEYLAYLGFNV-HENDSQLAAIHVTRERRIDLAKRQSSRSVYKCHVIGPKGSGK 459
            ||.|.:||.:.:|||.|||::: .|.:||.:||.|||:::|||.|:|:.|:|::|:|||.||.||
Mouse   380 TLTTYLDVQRCLEYLGYLGYSILTEQESQASAITVTRDKKIDLQKKQTQRNVFRCNVIGVKGCGK 444

  Fly   460 TGMCRGFLVEDM--HKLIGKEFKTNVVNCINSVQVYGQEKHLILRDIDVRHALDPLQPQEVNCDV 522
            ||:.:..|..::  .|.|..:.|:  ...||:|.||||||:|:|.||.   ..:.|...|..|||
Mouse   445 TGVLQSLLGRNLMRQKKIRDDHKS--YYAINTVYVYGQEKYLLLHDIS---ESEFLTEAETICDV 504

  Fly   523 ACLVYDSSNPRSFEYVARIYIKYYAESKIPVMIVGTKCDMDERRQDYLMQPSEFCDKYKLLPPHL 587
            .|||||.:||:||||.|||:.:::.:|:||.:||..|.|:.|.:|::.:.|::||.|:|:.||..
Mouse   505 VCLVYDVTNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEHSISPTDFCRKHKMPPPQA 569

  Fly   588 FSLKT---NKKELYTKLATMAAFP 608
            |:..|   ..|:::.||.|||.:|
Mouse   570 FTCNTADAPSKDIFVKLTTMAMYP 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Miro	NP_001262895.1	Miro1	10..195	CDD:206680	109/184 (59%)
		RHO	14..195	CDD:197554	106/180 (59%)
		EF_assoc_2	247..328	CDD:285547	49/80 (61%)
		EF_assoc_1	367..437	CDD:285546	30/70 (43%)
		Miro2	444..620	CDD:206679	73/170 (43%)
		Ras	448..602	CDD:278499	66/158 (42%)
Rhot1	XP_006533949.1	Miro1	16..182	CDD:206680	109/184 (59%)
		EF_assoc_2	232..316	CDD:369829	52/83 (63%)
		EF_assoc_1	354..423	CDD:369828	31/71 (44%)
		Miro2	428..593	CDD:206679	72/169 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	211	1.000	Domainoid score	I2792
eggNOG	1	0.900	-	-		E2759_KOG1707
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56803
Inparanoid	1	1.050	637	1.000	Inparanoid score	I828
Isobase	1	0.950	-	0	Normalized mean entropy	S1464
OMA	1	1.010	-	-		QHG55756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001617
OrthoInspector	1	1.000	-	-		otm43655
orthoMCL	1	0.900	-	-		OOG6_101658
Panther	1	1.100	-	-	O	PTHR24072
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2129
SonicParanoid	1	1.000	-	-		X1026
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810