DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Miro and rhot1b

DIOPT Version :9

Sequence 1:	NP_001262895.1	Gene:	Miro / 42845	FlyBaseID:	FBgn0039140	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_001076295.2	Gene:	rhot1b / 561933	ZFINID:	ZDB-GENE-061009-52	Length:	660	Species:	Danio rerio

Alignment Length:	685	Identity:	334/685 - (48%)
Similarity:	463/685 - (67%)	Gaps:	58/685 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RKNVRILLVGDAGVGKTSLILSLVSEEYPEEVPPRAEEITIPANVTPEQVPTSIVDFSAVEQSED 73
            ||:|||||||:..|||||||:||||||:|..||.|||||||||:||||:|||.|||:|..||:::
Zfish     2 RKDVRILLVGEPKVGKTSLIMSLVSEEFPAVVPYRAEEITIPADVTPERVPTHIVDYSEAEQTDE 66

  Fly    74 ALAAEINKAHVVCIVYAVDDDDTLDRITSHWLPLVRAKCNPSLDGEGDAEAEAEGDTQREPIRKP 138
            .|..||:||:|:||||:|::..:::::||||:||:..:                  |.::. |.|
Zfish    67 QLFQEISKANVICIVYSVNNQKSIEKVTSHWIPLINER------------------TDKDS-RVP 112

  Fly   139 IVLVGNKIDLIEYSTMDSVLAIMEDYPEIESCVECSAKSLHNISEMFYYAQKAVLHPTSPLYMME 203
            ::|||||.||:|:|:|::||.||..|.|||:|||||||:|.||||:||||||||||||.|||..|
Zfish   113 LILVGNKSDLVEHSSMETVLPIMNKYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYCPE 177

  Fly   204 EQELTSACKKSLVRIFKICDIDGDNLLNDYELNLFQRRCFNTPLQPQILDEVKAVIQKNVPDGIY 268
            ::|:.:||..:|.||||:.|:|.|.:|||.||..||:.||||||.||.|::||.|::||:.||::
Zfish   178 KKEMRTACVLALTRIFKVSDLDNDGVLNDNELTFFQKTCFNTPLAPQALEDVKNVVRKNISDGVH 242

  Fly   269 NDAVTLKGFLFLHCLFIQRGRNETTWAVLRRFGYNDQLEMCQEYLRPPLKIPPGSSTELSHRGQQ 333
            ::.:|||||||||.|||||||:||||||||||||:|.||:.|:||.|||||||.|:|||:|....
Zfish   243 DNGLTLKGFLFLHTLFIQRGRHETTWAVLRRFGYDDDLELHQDYLFPPLKIPPDSTTELNHDAYL 307

  Fly   334 FLIAVFERYDRDGDGALSPEEHKMLFSTCPAAPWSYSTDIRKSCPINETTGWVTLHGWLCRWTLM 398
            ||.:||:::|:|.||:|||.|...||...|..||  ..|:..:...|: .||:|..|:|.:|||.
Zfish   308 FLQSVFDKHDKDRDGSLSPGELIDLFDVFPYVPW--GLDVNSTVCTND-QGWITYQGYLSQWTLT 369

  Fly   399 TLIDVVKTMEYLAYLGFN-VHENDSQLAAIHVTRERRIDLAKRQSSRSVYKCHVIGPKGSGKTGM 462
            |.:||.:.:|||.|||:: :.|.:||.:||.|||::::||.|:|:.|:|::|||.|..||||||.
Zfish   370 TYLDVQRCLEYLGYLGYSIIAEQESQASAITVTRDKKLDLQKKQTQRNVFRCHVFGITGSGKTGF 434

  Fly   463 CRGFLVEDM--HKLIGKEFKTNVVNCINSVQVYGQEKHLILRDI--DVRHALDPLQPQEVNCDVA 523
            .:|||..::  .:.|.:|.|:  ...|::..||||||:|:|..:  |    .|.|...|:.||||
Zfish   435 LQGFLGRNLVHQRAIREEHKS--YYAISTAHVYGQEKYLLLHKVFPD----FDFLSEMELTCDVA 493

  Fly   524 CLVYDSSNPRSFEYVARIYIKYYAESKIPVMIVGTKCDMDERRQDYLMQPSEFCDKYKLLPPHLF 588
            ||:||.|||.||||.|:|:.:|:.:||.|.|:...|.|:.|.:|.|.|.|.|||.|:|:.||..:
Zfish   494 CLIYDVSNPCSFEYCAQIFKQYFMDSKTPCMLTAAKSDLPETKQQYGMTPLEFCRKHKMPPPQSY 558

  Fly   589 SLKT---NKKELYTKLATMAAFPRFQAAWIL------------FYKHRLVQLWE--------SAH 630
            :..|   ..|:::.||||||.:|..:...:.            |....|||...        |.|
Zfish   559 TCNTAGAPSKDIFIKLATMAVYPHARLRCMCTCNRCTFCLCQNFLNSELVQTVRTKLYTVILSRH 623

  Fly   631 LRQFGLMTEDPKLWLKAGLGVAAATMLGFIVLKTI 665
            :....|  ::..|||||.:|.....:|||.:.:|:
Zfish   624 IIHAEL--KNSSLWLKASVGATICAVLGFALYRTL 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Miro	NP_001262895.1	Miro1	10..195	CDD:206680	105/184 (57%)
		RHO	14..195	CDD:197554	102/180 (57%)
		EF_assoc_2	247..328	CDD:285547	55/80 (69%)
		EF_assoc_1	367..437	CDD:285546	28/70 (40%)
		Miro2	444..620	CDD:206679	77/194 (40%)
		Ras	448..602	CDD:278499	68/160 (43%)
rhot1b	NP_001076295.2	Gem1	3..187	CDD:224025	115/202 (57%)
		Miro1	3..169	CDD:206680	105/184 (57%)
		EF_assoc_2	221..301	CDD:285547	54/79 (68%)
		EF-hand_6	309..333	CDD:290141	11/23 (48%)
		EF_assoc_1	341..409	CDD:285546	28/70 (40%)
		Miro2	415..582	CDD:206679	75/172 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2754
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	658	1.000	Inparanoid score	I750
OMA	1	1.010	-	-		QHG55756
OrthoDB	1	1.010	-	-		D239599at33208
OrthoFinder	1	1.000	-	-		FOG0001617
OrthoInspector	1	1.000	-	-		otm24818
orthoMCL	1	0.900	-	-		OOG6_101658
Panther	1	1.100	-	-	O	PTHR24072
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1026
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980