DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Miro and rhot2

DIOPT Version :9

Sequence 1:	NP_001262895.1	Gene:	Miro / 42845	FlyBaseID:	FBgn0039140	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_001032768.1	Gene:	rhot2 / 557574	ZFINID:	ZDB-GENE-051120-96	Length:	617	Species:	Danio rerio

Alignment Length:	661	Identity:	305/661 - (46%)
Similarity:	431/661 - (65%)	Gaps:	51/661 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RKNVRILLVGDAGVGKTSLILSLVSEEYPEEVPPRAEEITIPANVTPEQVPTSIVDFSAVEQSED 73
            :::|||||:|:..|||||||:|||.||:||:||.|||||||||:||||:|||.|||:|..||:::
Zfish     2 KRDVRILLLGEPKVGKTSLIMSLVGEEFPEQVPLRAEEITIPADVTPEKVPTHIVDYSENEQTDE 66

  Fly    74 ALAAEINKAHVVCIVYAVDDDDTLDRITSHWLPLVRAKCNPSLDGEGDAEAEAEGDTQREPIRKP 138
            .|..||.||:|||:||.|..::|:|:|.:.|:|||          .|.||..:         :.|
Zfish    67 VLREEIVKANVVCVVYDVTQEETIDKIRTKWIPLV----------NGGAEKGS---------KIP 112

  Fly   139 IVLVGNKIDLIEYSTMDSVLAIMEDYPEIESCVECSAKSLHNISEMFYYAQKAVLHPTSPLYMME 203
            |:|||||.||...|:|:::|.||..:.|||:|||||||:|.||||:||||||||||||:|||..|
Zfish   113 IILVGNKSDLRSGSSMETILPIMNQFSEIETCVECSAKNLKNISELFYYAQKAVLHPTAPLYDPE 177

  Fly   204 EQELTSACKKSLVRIFKICDIDGDNLLNDYELNLFQRRCFNTPLQPQILDEVKAVIQKNVPDGIY 268
            :::|.:.|.::|.|||.|.|.|.|::|:|.|||.||:.||..||.||.|::||.|:.||..||:.
Zfish   178 DKQLKAQCVRALSRIFSISDQDNDHILSDAELNCFQKLCFGNPLAPQALEDVKTVVWKNTSDGVQ 242

  Fly   269 NDAVTLKGFLFLHCLFIQRGRNETTWAVLRRFGYNDQLEMCQEYLRPPLKIPPGSSTELSHRGQQ 333
            ::.:||.|||||:.|||||||:||||.:||:|||:|.||:..:||.|.|::..|.:|||:|.|.|
Zfish   243 DNGLTLNGFLFLNTLFIQRGRHETTWTILRKFGYDDTLELTDDYLYPVLRVSVGCTTELNHLGHQ 307

  Fly   334 FLIAVFERYDRDGDGALSPEEHKMLFSTCPAAPWSYSTDIRKSCPINETTGWVTLHGWLCRWTLM 398
            ||:.:||:||.|.|.||||.|.|.|||..|..||  |:.:..:.|:.:.. :::.||:||:|.|:
Zfish   308 FLLKLFEKYDEDKDSALSPAELKNLFSVLPYMPW--SSTVYSNIPLTDDC-YISQHGYLCQWMLL 369

  Fly   399 TLIDVVKTMEYLAYLGFNV-HENDSQLAAIHVTRERRIDLAKRQSSRSVYKCHVIGPKGSGKTGM 462
            ..:||.:.:|:|.|||:.: .|.:.|.:||.||||:.:||..||:.|:|:.|.||||:|:|||..
Zfish   370 AYLDVHRCLEHLGYLGYPILMEQECQTSAITVTREKALDLDNRQTQRTVFLCKVIGPRGTGKTDF 434

  Fly   463 CRGFLVEDMHKLIGKEFKTNVVNCINSVQVYGQEKHLILRDIDVRHALDPLQPQEVNCDVACLVY 527
            .|.||.....: ..::.....:..||:|.:..|:|:|||.::||.  .:.|:..:..||||||:|
Zfish   435 LRAFLQRSTER-SDRDPGAPSIYAINTVSIANQDKYLILEEVDVE--TEFLKAADAACDVACLMY 496

  Fly   528 DSSNPRSFEYVARIYIKYYAESKIPVMIVGTKCDMDERRQDYLMQPSEFCDKYKLLPP-HLFSLK 591
            |.|:|.||.|.|.||.::|.:|.||.:::|:|.|:.|.:|.:.|.|||||.|::|..| |..:|.
Zfish   497 DVSDPDSFNYCASIYKQHYMDSGIPCVVLGSKADLVEVKQHHGMSPSEFCYKHRLPSPLHFSALL 561

  Fly   592 TN-KKELYTKLATMAAFPRFQAAWILFYKHRLVQLWESAHLRQFGLMTEDPKLWLKAGLGVAAAT 655
            |: ...:|:||...|.:|                     ||.  |........||:..||...|.
Zfish   562 THTHTHIYSKLTWAAMYP---------------------HLN--GSDMSSTSFWLRVTLGATIAA 603

  Fly   656 MLGFIVLKTIS 666
            ||||.:.:..|
Zfish   604 MLGFALYRAFS 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Miro	NP_001262895.1	Miro1	10..195	CDD:206680	103/184 (56%)
		RHO	14..195	CDD:197554	101/180 (56%)
		EF_assoc_2	247..328	CDD:285547	44/80 (55%)
		EF_assoc_1	367..437	CDD:285546	24/70 (34%)
		Miro2	444..620	CDD:206679	67/177 (38%)
		Ras	448..602	CDD:278499	62/155 (40%)
rhot2	NP_001032768.1	Miro1	3..169	CDD:206680	103/184 (56%)
		RHO	7..169	CDD:197554	101/180 (56%)
		EF_assoc_2	221..301	CDD:285547	43/79 (54%)
		EF_assoc_1	341..409	CDD:285546	24/70 (34%)
		Miro2	415..591	CDD:206679	70/201 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2754
eggNOG	1	0.900	-	-		E2759_KOG1707
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	658	1.000	Inparanoid score	I750
OMA	1	1.010	-	-		QHG55756
OrthoDB	1	1.010	-	-		D239599at33208
OrthoFinder	1	1.000	-	-		FOG0001617
OrthoInspector	1	1.000	-	-		otm24818
orthoMCL	1	0.900	-	-		OOG6_101658
Panther	1	1.100	-	-	LDO	PTHR24072
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2129
SonicParanoid	1	1.000	-	-		X1026
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870