DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Miro and RhoBTB

DIOPT Version :9

Sequence 1:	NP_001262895.1	Gene:	Miro / 42845	FlyBaseID:	FBgn0039140	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	99/517 - (19%)
Similarity:	162/517 - (31%)	Gaps:	197/517 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VRILLVGDAGVGKTSLILS-----------LVSEEYP-----------EEVPPRAEEITIPANVT 54
            |:.:||||..||||.||.:           |:|...|           ::|..|:.|:....||:
  Fly    14 VKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERSWEVVDGVNVS 78

  Fly    55 PEQVPTSIVDFSAVEQSEDALAAEINKAHVVCIVYAVDDDDTLDRITSHWLPLVRAKCNPSLDGE 119
            .....|    |.  :..:|...| ..::.||.:.:::....:|......|.|.:|..| |.:
  Fly    79 LRLWDT----FG--DHDKDRRFA-YGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFC-PDV--- 132

  Fly   120 GDAEAEAEGDTQREPIRKPIVLVGNKIDLIEYSTMDSVLAIMEDYPEIESCVECSAKSLHNISEM 184
                              |::|||.|.|| .|...|      |:|                   :
  Fly   133 ------------------PVILVGCKNDL-RYMYRD------ENY-------------------L 153

  Fly   185 FYYAQKAVLHPTSPLYMMEEQELTSACKKSLVRIFKICDIDGDNLLNDYELNLFQRRCFNTPLQP 249
            .|:.:|...             :.:|.|..||
  Fly   154 SYFGEKGTF-------------VRAALKSDLV--------------------------------- 172

  Fly   250 QILDEVKAVIQKNVPDGIYNDAVTLKGFLFLHCLFIQRGRNETTWAVLR---------RFGYND- 304
             :.||.:|| .|.:....|..:|           |...|.||.....:|         ||...:
  Fly   173 -MPDEARAV-AKELGVAYYETSV-----------FTYFGVNEVFENAIRSALIARRQQRFWMTNL 224

  Fly   305 ---QLEMCQEYLRPPLKIPPGSSTELSHRGQ----QFLIAVFERYDRDGDGALSPEEHK-MLFST 361
               |..:.|...|||...||..:..:.:..|    .||...:......|.|......|: ||.:.
  Fly   225 KKVQKPLLQAPFRPPKPPPPEVTVMVGNYRQDIYNMFLSQAYTDLVLVGAGGTKFAVHRFMLAAA 289

  Fly   362 CPAAPWSYSTDI--------RKSCPINETTGWVTLHGW------LCRWTLMTLIDVVKTMEYL-- 410
            ........||::        .:|..::.|.|..|:..:      |.|:...|    .:..|:|
  Fly   290 SSIFQRLLSTELTDMGGRSSSESSMVSSTFGEATIADFNDDTEALIRYESRT----QRMWEHLKR 350

  Fly   411 --AYLGFNVHE----ND----------SQLAAIHVTRERRID-------LAKRQSSRSVYKC 449
              :|....:.|    ||          ..:..:||...|.::       |:|..|.:::::|
  Fly   351 RSSYQALPLMESKRSNDLYRELHHPVLQSIRLVHVENHRGVNGLQTIVTLSKLISPQALHQC 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Miro	NP_001262895.1	Miro1	10..195	CDD:206680	44/204 (22%)
		RHO	14..195	CDD:197554	43/202 (21%)
		EF_assoc_2	247..328	CDD:285547	21/93 (23%)
		EF_assoc_1	367..437	CDD:285546	18/108 (17%)
		Miro2	444..620	CDD:206679	1/6 (17%)
		Ras	448..602	CDD:278499	1/2 (50%)
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	60/309 (19%)
		RHO	16..211	CDD:197554	59/308 (19%)
		BTB	<392..446	CDD:295341	4/21 (19%)
		BTB	481..575	CDD:279045
		BTB	485..582	CDD:197585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466328
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24072
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030