DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Miro and Rhot1

DIOPT Version :9

Sequence 1:	NP_001262895.1	Gene:	Miro / 42845	FlyBaseID:	FBgn0039140	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	XP_017452795.1	Gene:	Rhot1 / 303351	RGDID:	1307023	Length:	704	Species:	Rattus norvegicus

Alignment Length:	718	Identity:	329/718 - (45%)
Similarity:	460/718 - (64%)	Gaps:	87/718 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ASQRKNVRILLVGDAGVGKTSLILSLVSEEYPEEVPPRAEEITIPANVTPEQVPTSIVDFSAVEQ 70
            :..:|:|||||||:..|||||||:||||||:|||||||||||||||:||||:|||.|||:|..||
  Rat    12 SDMKKDVRILLVGEPRVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSEAEQ 76

  Fly    71 SEDALAAEINKAHVVCIVYAVDDDDTLDRITSHWLPLVRAKCNPSLDGEGDAEAEAEGDTQREPI 135
            |::.|..||::|:|:||||||::..::|::||.|:||:..:                  |.::.
  Rat    77 SDEQLHQEISQANVICIVYAVNNKHSIDKVTSRWIPLINER------------------TDKDS- 122

  Fly   136 RKPIVLVGNKIDLIEYSTMDSVLAIMEDYPEIESCVECSAKSLHNISEMFYYAQKAVLHPTSPLY 200
            |.|::|||||.||:|||:|:::|.||..|.|||:|||||||:|.||||:||||||||||||.|||
  Rat   123 RLPLILVGNKSDLVEYSSMETILPIMNQYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLY 187

  Fly   201 MMEEQELTSACKKSLVRIFKICDIDGDNLLNDYELNLFQRRCFNTPLQPQILDEVKAVIQKNVPD 265
            ..||:|:..||.|:|.|||||.|.|.|..|||.|||.|||.||||||.||.|::||.|::|::.|
  Rat   188 CPEEKEMKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVKNVVRKHLSD 252

  Fly   266 GIYNDAVTLKGFLFLHCLFIQRGRNETTWAVLRRFGYNDQLEMCQEYLRPPLKIPPGSSTELSHR 330
            |:.:..:||:||||||.|||||||:||||.|||||||:|.|::..|||.|.|||||..:|||:|.
  Rat   253 GVADSGLTLRGFLFLHTLFIQRGRHETTWTVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTELNHH 317

  Fly   331 GQQFLIAVFERYDRDGDGALSPEEHKMLFSTCPAAPWSYSTDIRKSCPINETTGWVTLHGWLCRW 395
            ...||.:.|:::|.|.|.||||:|.|.||...|..||  ..|:..:...|| :||:|..|:|.:|
  Rat   318 AYLFLQSTFDKHDLDRDCALSPDELKDLFQVFPYIPW--GPDVNNTVCTNE-SGWITYQGFLSQW 379

  Fly   396 TLMTLIDVVKTMEYLAYLGFNV-HENDSQLAAIHVTRERRIDLAKRQSSRSVYKCHVIGPKGSGK 459
            ||.|.:||.:.:|||.|||::: .|.:||.:||.|||:::|||.|:|:.|:|::|:|||.||.||
  Rat   380 TLTTYLDVQRCLEYLGYLGYSILTEQESQASAITVTRDKKIDLQKKQTQRNVFRCNVIGVKGCGK 444

  Fly   460 TGMCRGFLVEDM--HKLIGKEFKTNVVNCINSVQVYGQEKHLILRDIDVRHALDPLQPQEVNCDV 522
            ||:.:..|..::  .|.|..:.|:  ...||:|.||||||:|:|.||.   ..:.|...|:.|||
  Rat   445 TGVLQSLLGRNLMRQKKIRDDHKS--YYAINTVYVYGQEKYLLLHDIS---ESEFLTEAEIVCDV 504

  Fly   523 ACLVYDSSNPRSFEYVARIYIKYYAESKIPVMIVGTKCDMDERRQDYLMQPSEFCDKYKLLPPHL 587
            .|||||.:||:||||.|||:.:::.:|:||.:||..|.|:.|.:|::.:.|::||.|:|:.||..
  Rat   505 VCLVYDVTNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEHSVSPTDFCRKHKMPPPQA 569

  Fly   588 FSLKT---NKKELYTKLATMAAFP-------------------RFQAAWILF------------- 617
            |:..|   ..|:::.||.|||.:|                   ..:..|:..
  Rat   570 FTCNTADAPSKDIFVKLTTMAMYPEDHYRGSLSRDMGSTDRIENLRKIWVFLKTAFHARLRCMCT 634

  Fly   618 --------------------YKHRLVQLWESAHLRQFGLMTEDPKLWLKAGLGVAAATMLGFIVL 662
                                .|:::.....:.|:.|..|  :....||:|..|.....::||.:.
  Rat   635 CNRCTFCICQNLLNSDLLQSVKNKVFTAVLNRHVTQADL--KSSTFWLRASFGATVFAVVGFAMY 697

  Fly   663 KTI 665
            :.:
  Rat   698 RAL 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Miro	NP_001262895.1	Miro1	10..195	CDD:206680	109/184 (59%)
		RHO	14..195	CDD:197554	106/180 (59%)
		EF_assoc_2	247..328	CDD:285547	49/80 (61%)
		EF_assoc_1	367..437	CDD:285546	30/70 (43%)
		Miro2	444..620	CDD:206679	74/232 (32%)
		Ras	448..602	CDD:278499	66/158 (42%)
Rhot1	XP_017452795.1	Miro1	16..182	CDD:206680	109/184 (59%)
		EF_assoc_2	232..316	CDD:400591	52/83 (63%)
		EF_assoc_1	354..423	CDD:400590	31/71 (44%)
		Miro2	428..593	CDD:206679	72/169 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	211	1.000	Domainoid score	I2704
eggNOG	1	0.900	-	-		E2759_KOG1707
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56803
Inparanoid	1	1.050	625	1.000	Inparanoid score	I827
OMA	1	1.010	-	-		QHG55756
OrthoDB	1	1.010	-	-		D239599at33208
OrthoFinder	1	1.000	-	-		FOG0001617
OrthoInspector	1	1.000	-	-		otm45729
orthoMCL	1	0.900	-	-		OOG6_101658
Panther	1	1.100	-	-	O	PTHR24072
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1026
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880