Protein Alignment Miro and Rhot2

DIOPT Version :10

• Sequence 1: NP_651205.2
• Gene: Miro / 42845
• FlyBaseID: FBgn0039140
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_666111.1
• Gene: Rhot2 / 214952
• MGIID: 2384892
• Length: 620
• Species: Mus musculus
• Alignment Length: 666
• Identity: 313/666 - (46%)
• Similarity: 429/666 - (64%)
• Gaps: 60/666 - (9%)

  Fly     9 RKNVRILLVGDAGVGKTSLILSLVSEEYPEEVPPRAEEITIPANVTPEQVPTSIVDFSAVEQSED 73
            |::|||||:|:|.|||||||||||.||:|||||.|||||||||:||||:|||.|||:|..||:|:
Mouse     2 RRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPARAEEITIPADVTPEKVPTHIVDYSEAEQTEE 66

  Fly    74 ALAAEINKAHVVCIVYAVDDDDTLDRITSHWLPLVRAKCNPSLDGEGDAEAEAEGDTQREPIRKP 138
            .|..||:||:|||:||.|.::.|:::|.:.|:|||                  .|.|...| |.|
Mouse    67 ELQEEIHKANVVCVVYDVSEETTIEKIRTKWIPLV------------------NGRTATGP-RLP 112

  Fly   139 IVLVGNKIDLIEYSTMDSVLAIMEDYPEIESCVECSAKSLHNISEMFYYAQKAVLHPTSPLYMME 203
            |:|||||.||...|||::||.||..:||||:|||||||.|.||||:||||||||||||:|||..|
Mouse   113 IILVGNKSDLRPGSTMEAVLPIMSQFPEIETCVECSAKHLRNISELFYYAQKAVLHPTAPLYDPE 177

  Fly   204 EQELTSACKKSLVRIFKICDIDGDNLLNDYELNLFQRRCFNTPLQPQILDEVKAVIQKNVPDGIY 268
            .::|..||.::|.|||::.|.|.|:.|:|.|||.||:.||..||.||.|::||.|:.|||..|:.
Mouse   178 AKQLRPACAQALTRIFRLSDQDRDHGLSDEELNAFQKSCFGHPLAPQALEDVKRVVCKNVSGGVQ 242

  Fly   269 NDAVTLKGFLFLHCLFIQRGRNETTWAVLRRFGYNDQLEMCQEYLRPPLKIPPGSSTELSHRGQQ 333
            ||.:||:|||||:.|||||||:||||.:||||||:|.||:..:||.|.|.:|||.||||:|||.|
Mouse   243 NDRLTLEGFLFLNTLFIQRGRHETTWTILRRFGYSDSLELTPDYLYPALHVPPGCSTELNHRGYQ 307

  Fly   334 FLIAVFERYDRDGDGALSPEEHKMLFSTCPAAPWSYSTDIRKSCPINETTGWVTLHGWLCRWTLM 398
            |:..:||::|:|.||.|||.|.:.|||....|||  ..::..:.|..  .|.:.|||:||:||||
Mouse   308 FVQRMFEKHDQDHDGVLSPTELQNLFSVFSGAPW--GPELLHTVPTQ--AGCLPLHGYLCQWTLM 368

  Fly   399 TLIDVVKTMEYLAYLGF-NVHENDSQLAAIHVTRERRIDLAKRQSSRSVYKCHVIGPKGSGKTGM 462
            |.:||.:.:.:|.|||: .:.|.|||..||.||||:::|..|.|:.|||..|.|:|.:|.||:..
Mouse   369 TYLDVQQCLAHLGYLGYPTLCEQDSQAQAITVTREKKLDQEKGQTQRSVLMCKVLGARGVGKSAF 433

  Fly   463 CRGFLVEDMHKLIGKEFKTNVVNCINSVQVYGQEKHLILRDIDVRHALDPLQPQEVNCDVACLVY 527
            .:.||...:.:......|. .::.||:|:|.||||:|||.:::....||  ...:..||||||::
Mouse   434 LQAFLGNSLGEARDPPEKF-PLHTINTVRVNGQEKYLILCEVNADSLLD--TSLDTTCDVACLMF 495

  Fly   528 DSSNPRSFEYVARIYIKYYAESKIPVMIVGTKCDMDERRQDYLMQPSEFCDKYKLLPPHLFSL-- 590
            |||:|::|.:.|.||.:||.:.:.|.:.:.:|.|:.|......:.|:|||.:::|..|..||.
Mouse   496 DSSDPKTFVHCATIYKRYYMDGQTPCLFIASKADLPEGVAPPGLSPAEFCRRHRLPAPASFSCLG 560

  Fly   591 -KTNKKELYTKLATMAAFPRFQAAWILFYKHRLVQLWESAHLRQFGLMTE--DPKLWLK---AGL 649
             .....:::|:|||||.||                     ||    :.||  ....||:   ..:
Mouse   561 PAMPSTDVFTQLATMATFP---------------------HL----VHTELHPTSFWLRGVLVAV 600

  Fly   650 GVAAATMLGFIVLKTI 665
            |.|.|.:|.|.:.:.:
Mouse   601 GTAVAAVLSFSLYRVL 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Miro	NP_651205.2	Miro1	10..195	CDD:206680	110/184 (60%)
		EF_assoc_2	245..329	CDD:462444	52/83 (63%)
		FRQ1	<333..>360	CDD:444056	13/26 (50%)
		EF_assoc_1	367..437	CDD:462443	29/70 (41%)
		Miro2	444..620	CDD:206679	61/178 (34%)
Rhot2	NP_666111.1	Miro1	3..169	CDD:206680	110/184 (60%)
		EF_assoc_2	220..303	CDD:462444	52/82 (63%)
		FRQ1	<307..>336	CDD:444056	15/28 (54%)
		EF_assoc_1	341..409	CDD:462443	30/71 (42%)
		Miro2	414..591	CDD:206679	65/204 (32%)