DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mettl3 and IME4

DIOPT Version :9

Sequence 1:	NP_651204.1	Gene:	Mettl3 / 42844	FlyBaseID:	FBgn0039139	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_011323.3	Gene:	IME4 / 852683	SGDID:	S000003160	Length:	600	Species:	Saccharomyces cerevisiae

Alignment Length:	488	Identity:	174/488 - (35%)
Similarity:	259/488 - (53%)	Gaps:	105/488 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 LEDTNDTCQQKEEEAKRKLEVD-DVDQPQEKTIKLESTVARKESTSLDAPDDIMMLLSMPSTREK 190
            |:.::.:|::|......|.|.| :.||...:.:.:.:......:..|              .||:
Yeast   110 LKSSSSSCEEKVSSLTTKPEADSEKDQLLGRLLGVLNWDVNVSNQGL--------------PREQ 160

  Fly   191 QSKQVGEEILELLTKPT----AKERSVAEKFKSHGGAQVMEF---CSHGTKVECLKAQQATAEMA 248
            .|.::...:.|   ||:    ||||:   |:.:    :|:|:   ||..:....|
Yeast   161 LSNRLQNLLRE---KPSSFQLAKERA---KYTT----EVIEYIPICSDYSHASLL---------- 205

  Fly   249 AKKKQERRDEKELRPDVDAGENVTGKVPKTESAAEDGEIIA---EVINNCEAESQESTDGSDTCS 310
                                        .|.....:.:|::   ..|:.|    ||:..|...|.
Yeast   206 ----------------------------STSVYIVNNKIVSLQWSKISAC----QENHPGLIECI 238

  Fly   311 SETTDKCTKLHFKKIIQAHTDESLGDCSFLNTCFHMATCKYVHYEVDTLPH----------INTN 365
            .      :|:||...|:..||.||||||:|:||..:.||:|:|| :..:|.          .:.|
Yeast   239 Q------SKIHFIPNIKPQTDISLGDCSYLDTCHKLNTCRYIHY-LQYIPSCLQERADRETASEN 296

  Fly   366 KPTDVKTKLSLKRSVDSSCTLY------PPQWIQCDLRFLDMTVLGKFAVVMADPPWDIHMELPY 424
            |  .:::.:|:......:|:.:      |.|||:||:|..|..|||||:||:|||.|:|||.|||
Yeast   297 K--RIRSNVSIPFYTLGNCSAHCIKKALPAQWIRCDVRKFDFRVLGKFSVVIADPAWNIHMNLPY 359

  Fly   425 GTMSDDEMRALGVPALQDDGLIFLWVTGRAMELGRDCLKLWGYERVDELIWVKTNQLQRIIRTGR 489
            ||.:|.|:..|.:..|||:|:|||||||||:|||::.|..|||..::|:.|:|||||.|.|.|||
Yeast   360 GTCNDIELLGLPLHELQDEGIIFLWVTGRAIELGKESLNNWGYNVINEVSWIKTNQLGRTIVTGR 424

  Fly   490 TGHWLNHGKEHCLVGMKGNPTNLNRGLDCDVIVAEVRATSHKPDEIYGIIERLSPGT--RKIELF 552
            |||||||.|||.|||:||||..:|:.:|.|:||:..|.||.||||:|||.|||: ||  ||:|:|
Yeast   425 TGHWLNHSKEHLLVGLKGNPKWINKHIDVDLIVSMTRETSRKPDELYGIAERLA-GTHARKLEIF 488

  Fly   553 GRPHNIQPNWITLGNQLDGIRLVDPELITQFQK 585
            ||.||.:|.|.|:||||.|..:.:.::..::|:
Yeast   489 GRDHNTRPGWFTIGNQLTGNCIYEMDVERKYQE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mettl3	NP_651204.1	MT-A70	407..568	CDD:282866	99/162 (61%)
IME4	NP_011323.3	DEAD-like_helicase_N	<21..>98	CDD:421690
IME4	NP_011323.3	IME4	324..524	CDD:227069	115/199 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343065
Domainoid	1	1.000	218	1.000	Domainoid score	I469
eggNOG	1	0.900	-	-		E1_COG4725
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1917
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006500
OrthoInspector	1	1.000	-	-		oto99754
orthoMCL	1	0.900	-	-		OOG6_103808
Panther	1	1.100	-	-	LDO	PTHR12829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9617
SonicParanoid	1	1.000	-	-		X4741
TreeFam	1	0.960	-	-
	12	11.680