DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mettl3 and METTL14

DIOPT Version :9

Sequence 1:NP_651204.1 Gene:Mettl3 / 42844 FlyBaseID:FBgn0039139 Length:608 Species:Drosophila melanogaster
Sequence 2:NP_066012.1 Gene:METTL14 / 57721 HGNCID:29330 Length:456 Species:Homo sapiens


Alignment Length:399 Identity:106/399 - (26%)
Similarity:161/399 - (40%) Gaps:122/399 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   253 QERRDEKELRPDVDAGENVTGKVPKTESAAEDGEIIAEVINNCEAESQESTDGSDTC--SSET-- 313
            ||.|:.::||..:.|          .:..||..:.|..|:|: :.|.:|..:..:||  |.:|  
Human     6 QEIRERQKLRRQLLA----------QQLGAESADSIGAVLNS-KDEQREIAETRETCRASYDTSA 59

  Fly   314 ------------TDKCTKLHFKKIIQAHTDES---------------LGDCSFLNTCFHMATCKY 351
                        ||:.....:|..::...||.               |.....||.  |...|: 
Human    60 PNAKRKYLDEGETDEDKMEEYKDELEMQQDEENLPYEEEIYKDSSTFLKGTQSLNP--HNDYCQ- 121

  Fly   352 VHYEVDTLPHINTNKPTDV------------------KTKLSLKRSVDSSCTLYPPQWIQCDLRF 398
             |: ||| .|...|...||                  |.:|..|.:.       ||.::|.|:..
Human   122 -HF-VDT-GHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNT-------PPMYLQADIEA 176

  Fly   399 LDMTVL-GKFAVVMADPP------------------WDIHMELPYGTMSDDEMRALGVPALQDDG 444
            .|:..| .||.|::.:||                  ||..|:|        |:..:..|.    .
Human   177 FDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKL--------EIDEIAAPR----S 229

  Fly   445 LIFLWV-TGRAMELGRDCLKLWGYERVDELIWVKTNQLQRIIRTGRTGHW-----LNHGKEHCLV 503
            .||||. :|..::|||.||:.|||.|.:::.|:|||:    ...|:|...     ....|||||:
Human   230 FIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNK----NNPGKTKTLDPKAVFQRTKEHCLM 290

  Fly   504 GMKGNPTN------LNRGLDCDVIVAEVRATSH--KPDEIYGIIERLSPGTRKIELFGRPHNIQP 560
            |:||....      ::..:|.|:|:.|.....:  ||.||:.|||....|.|::.||||...|:|
Human   291 GIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRP 355

  Fly   561 NWITLGNQL 569
            .|:|:|..|
Human   356 GWLTVGPTL 364

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Mettl3NP_651204.1 MT-A70 407..568 CDD:282866 60/192 (31%)
METTL14NP_066012.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..75 6/24 (25%)