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Protein Alignment Mettl3 and METTL3

DIOPT Version :9

Sequence 1:	NP_651204.1	Gene:	Mettl3 / 42844	FlyBaseID:	FBgn0039139	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_062826.2	Gene:	METTL3 / 56339	HGNCID:	17563	Length:	580	Species:	Homo sapiens

Alignment Length:	656	Identity:	301/656 - (45%)
Similarity:	387/656 - (58%)	Gaps:	140/656 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADAW-DIKSLKTKRNTLREKLEKRKKERIEILSDIQEDLTNPKKEL------------------ 46
            |:|.| .|::.|.:.::|||:|::|:|:....|     ||.||:..|
Human     1 MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHL-----DLRNPEAALSPTFRSDSPVPTAPTSGG 60

  Fly    47 -----------VEADLEVQKEVLQALSSCSLALPIVSTQVVEKI----AGSSLEMVNFILGKLAN 96
                       :..|.|::|::|..||..:|.||..:..:...|    |.::.:.|..:|.|.|.
Human    61 PKPSTASAVPELATDPELEKKLLHHLSDLALTLPTDAVSICLAISTPDAPATQDGVESLLQKFAA 125

  Fly    97 QGAIVIRNVTIGTEAGCEIIS--------------VQPKELKEILEDTNDTCQQKEEE-----AK 142
            |..|.::...:..:|...:::              .:.|...|:........::.|::     |.
Human   126 QELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVAEKKGPGEVAGTVTGQKRRAEQDSTTVAAF 190

  Fly   143 RKLEVDDVDQPQEKTIKLESTVARKESTSLDAPDDIMMLLSMPSTREKQSKQVGEEILELLTKPT 207
            ....|..::....:..|..:..:||.:.| |...:|..||:..||:|:|||:|.:||||||...|
Human   191 ASSLVSGLNSSASEPAKEPAKKSRKHAAS-DVDLEIESLLNQQSTKEQQSKKVSQEILELLNTTT 254

  Fly   208 AKERSVAEKFKSHGGAQVMEFCSHGTKVECLKAQQATAEMAAKKKQERRDEKELRPDVDAGENVT 272
            |||:|:.|||:|.|.|||.|||.:|||.||:||..|.                 ||
Human   255 AKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDAD-----------------RP--------- 293

  Fly   273 GKVPKTESAAEDGEIIAEVINNCEAESQESTDGSDTCSSETTDKCTKLHFKKIIQAHTDESLGDC 337
                                                        |.||||::||..|||||||||
Human   294 --------------------------------------------CRKLHFRRIINKHTDESLGDC 314

  Fly   338 SFLNTCFHMATCKYVHYEVDT-----LPHINTNKPTDVKTKLSLKRSV--DSSC-TLYPPQWIQC 394
            |||||||||.||||||||:|.     .|....:.|:.   :|:|.:||  |||. .|:|||||.|
Human   315 SFLNTCFHMDTCKYVHYEIDACMDSEAPGSKDHTPSQ---ELALTQSVGGDSSADRLFPPQWICC 376

  Fly   395 DLRFLDMTVLGKFAVVMADPPWDIHMELPYGTMSDDEMRALGVPALQDDGLIFLWVTGRAMELGR 459
            |:|:||:::|||||||||||||||||||||||::|||||.|.:|.|||||.:|||||||||||||
Human   377 DIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGR 441

  Fly   460 DCLKLWGYERVDELIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGMKGNPTNLNRGLDCDVIVAE 524
            :||.|||||||||:|||||||||||||||||||||||||||||||:||||...|:||||||||||
Human   442 ECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAE 506

  Fly   525 VRATSHKPDEIYGIIERLSPGTRKIELFGRPHNIQPNWITLGNQLDGIRLVDPELITQFQKRYPD 589
            ||:||||||||||:|||||||||||||||||||:||||||||||||||.|:||:::.:|::||||
Human   507 VRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPD 571

  Fly   590 GNCMSP 595
            |....|
Human   572 GIISKP 577

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.