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Protein Alignment Mettl3 and Mettl3

DIOPT Version :9

Sequence 1:	NP_651204.1	Gene:	Mettl3 / 42844	FlyBaseID:	FBgn0039139	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_062695.2	Gene:	Mettl3 / 56335	MGIID:	1927165	Length:	580	Species:	Mus musculus

Alignment Length:	664	Identity:	303/664 - (45%)
Similarity:	388/664 - (58%)	Gaps:	156/664 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADAW-DIKSLKTKRNTLREKLEKRKKERIEILSDIQEDLTNPKKEL------------------ 46
            |:|.| .|::.|.:.::|||:|::|:|:....|     ||.||:..|
Mouse     1 MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHL-----DLRNPEAALSPTFRSDSPVPTAPTSSG 60

  Fly    47 -----------VEADLEVQKEVLQALSSCSLALPIVSTQVVEKI----AGSSLEMVNFILGKLAN 96
                       :..|.|::|::|..||..:|.||..:..:...|    |.::.:.|..:|.|.|.
Mouse    61 PKPSTTSVAPELATDPELEKKLLHHLSDLALTLPTDAVSIRLAISTPDAPATQDGVESLLQKFAA 125

  Fly    97 QGAIVIRNVTIGTEAGCEIIS--------------VQPKELKEILEDTNDTCQQKEEEAKRKLE- 146
            |..|.::...:..:|...:::              .:.|.|.|:.    .|...::..|::.|.
Mouse   126 QELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVAEKKGLGEVA----GTIAGQKRRAEQDLTT 186

  Fly   147 ------------VDDVDQPQEKTIKLESTVARKESTSLDAPDDIMMLLSMPSTREKQSKQVGEEI 199
                        .....:|.::..|    .:||.:.| |...:|..||:..||:|:|||:|.:||
Mouse   187 VTTFASSLASGLASSASEPAKEPAK----KSRKHAAS-DVDLEIESLLNQQSTKEQQSKKVSQEI 246

  Fly   200 LELLTKPTAKERSVAEKFKSHGGAQVMEFCSHGTKVECLKAQQATAEMAAKKKQERRDEKELRPD 264
            ||||...||||:|:.|||:|.|.|||.|||.:|||.||:||..|.                 ||
Mouse   247 LELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDAD-----------------RP- 293

  Fly   265 VDAGENVTGKVPKTESAAEDGEIIAEVINNCEAESQESTDGSDTCSSETTDKCTKLHFKKIIQAH 329
                                                                |.||||::||..|
Mouse   294 ----------------------------------------------------CRKLHFRRIINKH 306

  Fly   330 TDESLGDCSFLNTCFHMATCKYVHYEVDTL-----PHINTNKPTDVKTKLSLKRSV--DSSC-TL 386
            |||||||||||||||||.||||||||:|..     |....:.|:.   :|:|.:||  |||. .|
Mouse   307 TDESLGDCSFLNTCFHMDTCKYVHYEIDACVDSESPGSKEHMPSQ---ELALTQSVGGDSSADRL 368

  Fly   387 YPPQWIQCDLRFLDMTVLGKFAVVMADPPWDIHMELPYGTMSDDEMRALGVPALQDDGLIFLWVT 451
            :|||||.||:|:||:::|||||||||||||||||||||||::|||||.|.:|.|||||.:|||||
Mouse   369 FPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVT 433

  Fly   452 GRAMELGRDCLKLWGYERVDELIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGMKGNPTNLNRGL 516
            ||||||||:||.|||||||||:|||||||||||||||||||||||||||||||:||||...|:||
Mouse   434 GRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGL 498

  Fly   517 DCDVIVAEVRATSHKPDEIYGIIERLSPGTRKIELFGRPHNIQPNWITLGNQLDGIRLVDPELIT 581
            ||||||||||:||||||||||:|||||||||||||||||||:||||||||||||||.|:||:::.
Mouse   499 DCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVA 563

  Fly   582 QFQKRYPDGNCMSP 595
            :|::|||||....|
Mouse   564 RFKQRYPDGIISKP 577

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.