DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mettl3 and Mettl3

DIOPT Version :9

Sequence 1:	NP_651204.1	Gene:	Mettl3 / 42844	FlyBaseID:	FBgn0039139	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_001019965.1	Gene:	Mettl3 / 361035	RGDID:	1311750	Length:	580	Species:	Rattus norvegicus

Alignment Length:	660	Identity:	305/660 - (46%)
Similarity:	388/660 - (58%)	Gaps:	148/660 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADAW-DIKSLKTKRNTLREKLEKRKKERIEILSDIQEDLTNPKKEL------------------ 46
            |:|.| .|::.|.:.::|||:|::|:|:....|     ||.||:..|
  Rat     1 MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHL-----DLRNPEAALSPTFRSDSPVPTAPTSSG 60

  Fly    47 -----------VEADLEVQKEVLQALSSCSLALPIVSTQVVEKI----AGSSLEMVNFILGKLAN 96
                       :..|.|::|::|..||..:|.||..:..:...|    |.::.:.|..:|.|.|.
  Rat    61 PKPSTTSIVPELATDPELEKKLLHHLSDLALTLPTDAVSIRLAISTPDAPATQDGVESLLQKFAA 125

  Fly    97 QGAIVIR--------NVTIGTEAGCEIISVQPKEL--KEILEDTNDTCQQKEEEAKRKLEV---- 147
            |..|.::        :.|:.|.|....:|.....:  |:.|.:...|...::..|::.|..
  Rat   126 QELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVAEKKGLGEAAGTITGQKRRAEQDLTTVATF 190

  Fly   148 ---------DDVDQPQEKTIKLESTVARKESTSLDAPDDIMMLLSMPSTREKQSKQVGEEILELL 203
                     ....:|.::..|    .:||.:.| |...:|..||:..||:|:|||:|.:||||||
  Rat   191 TSSLASGLGSSTSEPAKEPAK----KSRKHAAS-DVDLEIESLLNQQSTKEQQSKKVSQEILELL 250

  Fly   204 TKPTAKERSVAEKFKSHGGAQVMEFCSHGTKVECLKAQQATAEMAAKKKQERRDEKELRPDVDAG 268
            ...||||:|:.|||:|.|.|||.|||.:|||.||:||..|.                 ||
  Rat   251 NTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDAD-----------------RP----- 293

  Fly   269 ENVTGKVPKTESAAEDGEIIAEVINNCEAESQESTDGSDTCSSETTDKCTKLHFKKIIQAHTDES 333
                                                            |.||||::||..|||||
  Rat   294 ------------------------------------------------CRKLHFRRIINKHTDES 310

  Fly   334 LGDCSFLNTCFHMATCKYVHYEVDTL-----PHINTNKPTDVKTKLSLKRSV--DSSC-TLYPPQ 390
            |||||||||||||.||||||||:|..     |....:.|:.   :|:|.:||  |||. .|:|||
  Rat   311 LGDCSFLNTCFHMDTCKYVHYEIDACVDSESPGSKEHMPSQ---ELALTQSVGGDSSADRLFPPQ 372

  Fly   391 WIQCDLRFLDMTVLGKFAVVMADPPWDIHMELPYGTMSDDEMRALGVPALQDDGLIFLWVTGRAM 455
            ||.||:|:||:::|||||||||||||||||||||||::|||||.|.:|.|||||.:|||||||||
  Rat   373 WICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAM 437

  Fly   456 ELGRDCLKLWGYERVDELIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGMKGNPTNLNRGLDCDV 520
            ||||:||.|||||||||:|||||||||||||||||||||||||||||||:||||...|:||||||
  Rat   438 ELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDV 502

  Fly   521 IVAEVRATSHKPDEIYGIIERLSPGTRKIELFGRPHNIQPNWITLGNQLDGIRLVDPELITQFQK 585
            ||||||:||||||||||:|||||||||||||||||||:||||||||||||||.|:||:::.:|:.
  Rat   503 IVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKH 567

  Fly   586 RYPDGNCMSP 595
            |||||....|
  Rat   568 RYPDGVISKP 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mettl3	NP_651204.1	MT-A70	407..568	CDD:282866	141/160 (88%)
Mettl3	NP_001019965.1	MT-A70	389..550	CDD:368270	136/160 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338409
Domainoid	1	1.000	320	1.000	Domainoid score	I1202
eggNOG	1	0.900	-	-		E1_COG4725
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10501
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1434
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D383312at33208
OrthoFinder	1	1.000	-	-		FOG0006500
OrthoInspector	1	1.000	-	-		oto97415
orthoMCL	1	0.900	-	-		OOG6_103808
Panther	1	1.100	-	-	LDO	PTHR12829
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4741
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760