Protein Alignment Mettl3 and mettl3

DIOPT Version :10

• Sequence 1: NP_651204.1
• Gene: Mettl3 / 42844
• FlyBaseID: FBgn0039139
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_997945.1
• Gene: mettl3 / 100004398
• ZFINID: ZDB-GENE-030131-9498
• Length: 584
• Species: Danio rerio
• Alignment Length: 656
• Identity: 301/656 - (45%)
• Similarity: 388/656 - (59%)
• Gaps: 136/656 - (20%)

  Fly     1 MADAWD-IKSLKTKRNTLREKLEKRKKERIEILSDI--------QED-----LTNPKKELVE--A 49
            |:|.|. |::.|.:.::|||:|::|:|:..::.:::        :.|     :.:|.:..||  .
Zfish     1 MSDTWSHIQAHKKQLDSLRERLQRRRKDPTQLGTEVGSVESGSARSDSPGPAIQSPPQVEVEHPP 65

  Fly    50 DLEVQKEVLQALSSCSLALPIVSTQVVEKIAGS----SLEMVNFILGKLANQGAIVIRNVTIGTE 110
            |.|::|.:|..||..||:||..|..:..::..|    |...:..:|.|.:.|..|.:|..:|.:.
Zfish    66 DPELEKRLLGYLSELSLSLPTDSLTITNQLNTSESPVSHSCIQSLLLKFSAQELIEVRQPSITSS 130

  Fly   111 AGCEII-SVQPKELKEILEDTNDTCQQKEEEAKRKLEVDDVDQPQ-----EKTIKLESTVARKES 169
            :...:: ||...:|..::....   |.:....|||  .||:...:     ..:|:...:..||.|
Zfish   131 SSSTLVTSVDHTKLWAMIGSAG---QSQRTAVKRK--ADDITHQKRAPGSSPSIQAPPSPPRKSS 190

  Fly   170 TSLDAPD-------------------------------DIMMLLSMPSTREKQSKQVGEEILELL 203
            .||....                               :|..|||..||:|:|||:|.:||||||
Zfish   191 VSLATASISQLTASSGGGGGGADKKGRSNKVQASHLDMEIESLLSQQSTKEQQSKKVSQEILELL 255

  Fly   204 TKPTAKERSVAEKFKSHGGAQVMEFCSHGTKVECLKAQQATAEMAAKKKQERRDEKELRPDVDAG 268
            ...:|||:|:.|||:|.|.|||.|||.:|||.||::
Zfish   256 NTSSAKEQSIVEKFRSRGRAQVQEFCDYGTKEECVQ----------------------------- 291

  Fly   269 ENVTGKVPKTESAAEDGEIIAEVINNCEAESQESTDGSDTCSSETTDKCTKLHFKKIIQAHTDES 333
                                                     |.:|...||||||::||..|||||
Zfish   292 -----------------------------------------SGDTPQPCTKLHFRRIINKHTDES 315

  Fly   334 LGDCSFLNTCFHMATCKYVHYEVDTLPHINTNK--PTDVKTKLSLKRSVDSSCT--LYPPQWIQC 394
            |||||||||||||.||||||||:|:.|....:.  |.....:|.|..:|..|..  |:|.|||.|
Zfish   316 LGDCSFLNTCFHMDTCKYVHYEIDSPPEAEGDALGPQAGAAELGLHSTVGDSNVGKLFPSQWICC 380

  Fly   395 DLRFLDMTVLGKFAVVMADPPWDIHMELPYGTMSDDEMRALGVPALQDDGLIFLWVTGRAMELGR 459
            |:|:||:::|||||||||||||||||||||||::|||||.|.:|.|||||.:|||||||||||||
Zfish   381 DIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRKLNIPILQDDGFLFLWVTGRAMELGR 445

  Fly   460 DCLKLWGYERVDELIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGMKGNPTNLNRGLDCDVIVAE 524
            :||.||||:||||:|||||||||||||||||||||||||||||||:||||...||||||||||||
Zfish   446 ECLSLWGYDRVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNRGLDCDVIVAE 510

  Fly   525 VRATSHKPDEIYGIIERLSPGTRKIELFGRPHNIQPNWITLGNQLDGIRLVDPELITQFQKRYPD 589
            ||:||||||||||:|||||||||||||||||||:||||||||||||||.|:|||::.:|:|||||
Zfish   511 VRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPEVVARFKKRYPD 575

  Fly   590 GNCMSP 595
            |....|
Zfish   576 GVISKP 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mettl3	NP_651204.1	MT-A70	407..568	CDD:368270	141/160 (88%)
mettl3	NP_997945.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65		15/63 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..221		9/60 (15%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q86U44	213..220		0/6 (0%)
		MT-A70	393..554	CDD:368270	141/160 (88%)
		Gate loop 1. /evidence=ECO:0000250|UniProtKB:Q86U44	400..414		13/13 (100%)
		Interaction with METTL14. /evidence=ECO:0000250|UniProtKB:Q86U44	454..458		2/3 (67%)
		Interphase loop. /evidence=ECO:0000250|UniProtKB:Q86U44	466..483		16/16 (100%)
		Interaction with METTL14. /evidence=ECO:0000250|UniProtKB:Q86U44	468..484		15/15 (100%)
		Positively charged region required for RNA-binding. /evidence=ECO:0000250|UniProtKB:Q86U44	469..482		12/12 (100%)
		Gate loop 2. /evidence=ECO:0000250|UniProtKB:Q86U44	511..519		6/7 (86%)