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Protein Alignment Mettl3 and mettl3

DIOPT Version :9

Sequence 1:	NP_651204.1	Gene:	Mettl3 / 42844	FlyBaseID:	FBgn0039139	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_997945.1	Gene:	mettl3 / 100004398	ZFINID:	ZDB-GENE-030131-9498	Length:	584	Species:	Danio rerio

Alignment Length:	656	Identity:	301/656 - (45%)
Similarity:	388/656 - (59%)	Gaps:	136/656 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADAWD-IKSLKTKRNTLREKLEKRKKERIEILSDI--------QED-----LTNPKKELVE--A 49
            |:|.|. |::.|.:.::|||:|::|:|:..::.:::        :.|     :.:|.:..||  .
Zfish     1 MSDTWSHIQAHKKQLDSLRERLQRRRKDPTQLGTEVGSVESGSARSDSPGPAIQSPPQVEVEHPP 65

  Fly    50 DLEVQKEVLQALSSCSLALPIVSTQVVEKIAGS----SLEMVNFILGKLANQGAIVIRNVTIGTE 110
            |.|::|.:|..||..||:||..|..:..::..|    |...:..:|.|.:.|..|.:|..:|.:.
Zfish    66 DPELEKRLLGYLSELSLSLPTDSLTITNQLNTSESPVSHSCIQSLLLKFSAQELIEVRQPSITSS 130

  Fly   111 AGCEII-SVQPKELKEILEDTNDTCQQKEEEAKRKLEVDDVDQPQ-----EKTIKLESTVARKES 169
            :...:: ||...:|..::....   |.:....|||  .||:...:     ..:|:...:..||.|
Zfish   131 SSSTLVTSVDHTKLWAMIGSAG---QSQRTAVKRK--ADDITHQKRAPGSSPSIQAPPSPPRKSS 190

  Fly   170 TSLDAPD-------------------------------DIMMLLSMPSTREKQSKQVGEEILELL 203
            .||....                               :|..|||..||:|:|||:|.:||||||
Zfish   191 VSLATASISQLTASSGGGGGGADKKGRSNKVQASHLDMEIESLLSQQSTKEQQSKKVSQEILELL 255

  Fly   204 TKPTAKERSVAEKFKSHGGAQVMEFCSHGTKVECLKAQQATAEMAAKKKQERRDEKELRPDVDAG 268
            ...:|||:|:.|||:|.|.|||.|||.:|||.||::
Zfish   256 NTSSAKEQSIVEKFRSRGRAQVQEFCDYGTKEECVQ----------------------------- 291

  Fly   269 ENVTGKVPKTESAAEDGEIIAEVINNCEAESQESTDGSDTCSSETTDKCTKLHFKKIIQAHTDES 333
                                                     |.:|...||||||::||..|||||
Zfish   292 -----------------------------------------SGDTPQPCTKLHFRRIINKHTDES 315

  Fly   334 LGDCSFLNTCFHMATCKYVHYEVDTLPHINTNK--PTDVKTKLSLKRSVDSSCT--LYPPQWIQC 394
            |||||||||||||.||||||||:|:.|....:.  |.....:|.|..:|..|..  |:|.|||.|
Zfish   316 LGDCSFLNTCFHMDTCKYVHYEIDSPPEAEGDALGPQAGAAELGLHSTVGDSNVGKLFPSQWICC 380

  Fly   395 DLRFLDMTVLGKFAVVMADPPWDIHMELPYGTMSDDEMRALGVPALQDDGLIFLWVTGRAMELGR 459
            |:|:||:::|||||||||||||||||||||||::|||||.|.:|.|||||.:|||||||||||||
Zfish   381 DIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRKLNIPILQDDGFLFLWVTGRAMELGR 445

  Fly   460 DCLKLWGYERVDELIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGMKGNPTNLNRGLDCDVIVAE 524
            :||.||||:||||:|||||||||||||||||||||||||||||||:||||...||||||||||||
Zfish   446 ECLSLWGYDRVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNRGLDCDVIVAE 510

  Fly   525 VRATSHKPDEIYGIIERLSPGTRKIELFGRPHNIQPNWITLGNQLDGIRLVDPELITQFQKRYPD 589
            ||:||||||||||:|||||||||||||||||||:||||||||||||||.|:|||::.:|:|||||
Zfish   511 VRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPEVVARFKKRYPD 575

  Fly   590 GNCMSP 595
            |....|
Zfish   576 GVISKP 581

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.