DRSC/TRiP Functional Genomics Resources

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Protein Alignment KrT95D and PACS1

DIOPT Version :9

Sequence 1:NP_524473.2 Gene:KrT95D / 42843 FlyBaseID:FBgn0020647 Length:1175 Species:Drosophila melanogaster
Sequence 2:NP_060496.2 Gene:PACS1 / 55690 HGNCID:30032 Length:963 Species:Homo sapiens


Alignment Length:1226 Identity:378/1226 - (30%)
Similarity:527/1226 - (42%) Gaps:361/1226 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 GPGGGPLNLQSGGGGGGSG-GGGGV-----------------------------SGSGGISGTAG 58
            |.||||     ||.||||| .|.||                             |.|...|..|.
Human     6 GAGGGP-----GGAGGGSGQRGSGVAQSPQQPPPQQQQQQPPQQPTPPKLAQATSSSSSTSAAAA 65

  Fly    59 LSAGAGMTT------------------GQKPVP--MKLFAAWEVDRTPPNCIPRLCSLTITRLSI 103
            .|:.:..:|                  |:.|.|  |.|:|.|||||:..:|:|||.|||:.:|.:
Human    66 SSSSSSTSTSMAVAVASGSAPPGGPGPGRTPAPVQMNLYATWEVDRSSSSCVPRLFSLTLKKLVM 130

  Fly   104 LTPLPGDTTSLSLAVKMQSSKRTLRSHEI--PINGLALTSSASLQGNSPMSVAGGVGGGGVGTPG 166
            |..:..|..|:.:|||:|.|||.|||:||  |.:|                              
Human   131 LKEMDKDLNSVVIAVKLQGSKRILRSNEIVLPASG------------------------------ 165

  Fly   167 SVGTGGGLGVAVPLTETELDLHFSLQYPHFIKRDGNRLVILLQRRKKYKSRTILGYKTLAEGIIR 231
                         |.||||.|.||||||||:|||.|:|.|:|||||:||:||||||||||.|:|.
Human   166 -------------LVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKNRTILGYKTLAVGLIN 217

  Fly   232 MDAVLQKSMD--MIIELTASGKNGRPGTVVACLRAERVSSIPVDHDNKNNNSVLLADR---VAEY 291
            |..|:|...:  :::.|.::.|:  ....||.::...:||.|:||:...:.   |:||   :..|
Human   218 MAEVMQHPNEGALVLGLHSNVKD--VSVPVAEIKIYSLSSQPIDHEGIKSK---LSDRSPDIDNY 277

  Fly   292 SDEDEEAEFSSGEFNDEANELGLIRGYDPKDPRDYNHPAKHDMRKYRNKLQRSGIEDCALVGHHP 356
            |:|:||:..|..|.:|           ||...:|..: ...|:||.:                  
Human   278 SEEEEESFSSEQEGSD-----------DPLHGQDLFY-EDEDLRKVK------------------ 312

  Fly   357 GSIQHHHPGVVVDSDSEFEMKDKSSSRAKFSRTISL-QQRNFKQKIVALLKRFKVSEELEGESGH 420
                                    .:|.|.:.|.:: :|.|.|||.||||||||||:|:.....|
Human   313 ------------------------KTRRKLTSTSAITRQPNIKQKFVALLKRFKVSDEVGFGLEH 353

  Fly   421 RGTAALRG-ERDLDALFQELESLSCCEGDDSGPDMDSI-SVGSTPKPSLRPFFTNSRIMLHDNIT 483
            .....:|. |.|||.|:..||..:   ..||||:|:.. |:.|||||.|:|||           .
Human   354 VSREQIREVEEDLDELYDSLEMYN---PSDSGPEMEETESILSTPKPKLKPFF-----------E 404

  Fly   484 GNGGDLSQLVGGGLGPGTGTAGNSERRSSDKSDQLTNSSYNLENNKNQKCIHLTNNNNSATTPDR 548
            |.....||...|.|. ..|:.|..           |.|...|...:..|...:.|.::|.|..| 
Human   405 GMSQSSSQTEIGSLN-SKGSLGKD-----------TTSPMELAALEKIKSTWIKNQDDSLTETD- 456

  Fly   549 GGNDSSGNEGNAGYTD----GQNSDPQNSPPRDKDYLRLQQMQQQQLTPVSSVAASM-GSGS--- 605
                      ....||    |..|.....|.:.|             ||:.|....: ||.|   
Human   457 ----------TLEITDQDMFGDASTSLVVPEKVK-------------TPMKSSKTDLQGSASPSK 498

  Fly   606 ---VITPAQTEKRSRLFRTSSNTPANAGSGGNSVSAISASGGGKRKHTLSLSAEPRSVLEACLSP 667
               |.||.|  |||        ||.........:|..:.|...:|...|..|.:           
Human   499 VEGVHTPRQ--KRS--------TPLKERQLSKPLSERTNSSDSERSPDLGHSTQ----------- 542

  Fly   668 TNVEPRKLLLDQLSRVFAGEDSAIPEVVTIISPPEALGGSALLAKLVTLFANSFKPAFVPQNTAE 732
               .|||::.|||:::.. .|:|:||.|.:::..:..|     ..:..|..:..||.....:|.|
Human   543 ---IPRKVVYDQLNQILV-SDAALPENVILVNTTDWQG-----QYVAELLQDQRKPVVCTCSTVE 598

  Fly   733 VKAVLQALMAKIQKYCNSNAKPPHTVKVLLIGGDWLQGATLRHYVELMGVRPPDWLNHLRFYLVP 797
            |:|||.||:.:||:|||.|:..|..|||..:||.....:.||.:|:.:..:..|||.::||.::|
Human   599 VQAVLSALLTRIQRYCNCNSSMPRPVKVAAVGGQSYLSSILRFFVKSLANKTSDWLGYMRFLIIP 663

  Fly   798 VGGSCGSVARHLSQMDQAYAVMFGSDNWTQLCERAAATAAAVSAVTTVNATALTTNLADAAGVAK 862
            :|..  .||::|..:|..|:..|....|..|..|:...               .:...|.||   
Human   664 LGSH--PVAKYLGSVDSKYSSSFLDSGWRDLFSRSEPP---------------VSEQLDVAG--- 708

  Fly   863 SDIAELVQRIQRYLLAAGPCTQIPIAEAMV----NYKDEDSCQIFVPFVSDVRIGYLDAQASLDL 923
                    |:.:|:..|....|:|:||||:    .:.||||.|.|:||:..|::|.::...|.  
Human   709 --------RVMQYVNGAATTHQLPVAEAMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSPST-- 763

  Fly   924 EENAAGSNAVGSGLGSGSASSSAIPIGSQSSPNVHGVVSGSPPQQQSLGRISPPLQTPPSSASSH 988
                         .|.|..|    |:.|.:.|      |.|||....|.|  ....|||||    
Human   764 -------------AGDGDDS----PVVSLTVP------STSPPSSSGLSR--DATATPPSS---- 799

  Fly   989 RERNTSESLSTPSSVQQQSFSGALAA--------AEAVELQVDYWPLVRPGEGHAKESKGGLSKG 1045
                             .|.|.|||.        .:.:.|||||| |..|||...:..|      
Human   800 -----------------PSMSSALAIVGSPNSPYGDVIGLQVDYW-LGHPGERRREGDK------ 840

  Fly  1046 SDAGGKNSIKSTFRNLQVWRLPQ--HAQQLGDMFNGLTVSFATKEKKQKQIMRLGKKKDKERDLE 1108
            .||..||::||.||::||.|||.  .||..|.|  .:||  .||||.:|.......||.:|::::
Human   841 RDASSKNTLKSVFRSVQVSRLPHSGEAQLSGTM--AMTV--VTKEKNKKVPTIFLSKKPREKEVD 901

  Fly  1109 -KEQCVEGVARLICSPKQSHPVPLRVYIDGTEWTGVKFFQVSSQWQTHVKNFPIAL 1163
             |.|.:||::|||||.||...: |||.|||.||:.:||||:::||.||||:||:.|
Human   902 SKSQVIEGISRLICSAKQQQTM-LRVSIDGVEWSDIKFFQLAAQWPTHVKHFPVGL 956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KrT95DNP_524473.2 Pacs-1 676..1167 CDD:287256 166/503 (33%)
PACS1NP_060496.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..72 20/70 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 78..97 1/18 (6%)
Involved in binding to AP-1 168..175 5/6 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..299 13/50 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 377..428 22/76 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 476..542 22/88 (25%)
Pacs-1 548..960 CDD:402045 166/503 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 760..804 19/91 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147149
Domainoid 1 1.000 225 1.000 Domainoid score I2541
eggNOG 1 0.900 - - E1_KOG3709
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 432 1.000 Inparanoid score I1718
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45439
OrthoDB 1 1.010 - - D151297at33208
OrthoFinder 1 1.000 - - FOG0002262
OrthoInspector 1 1.000 - - otm41468
orthoMCL 1 0.900 - - OOG6_102151
Panther 1 1.100 - - O PTHR13280
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4164
SonicParanoid 1 1.000 - - X1495
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

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