Protein Alignment KrT95D and PACS2

DIOPT Version :9

• Sequence 1: NP_524473.2
• Gene: KrT95D / 42843
• FlyBaseID: FBgn0020647
• Length: 1175
• Species: Drosophila melanogaster
• Sequence 2: XP_006720153.1
• Gene: PACS2 / 23241
• HGNCID: 23794
• Length: 905
• Species: Homo sapiens
• Alignment Length: 1151
• Identity: 354/1151 - (30%)
• Similarity: 509/1151 - (44%)
• Gaps: 296/1151 - (25%)

  Fly    55 GTAGLSAGAGMTTGQKPVPMKLFAAWEVDRTPPNCIPRLCSLTITRLSILTPLPGDTTSLSLAVK 119
            |..||....|..  ..||||.|||.||||.:.|:|:|||||||:.:|.:...|..:..|:.:|||
Human     5 GRLGLPGAPGAL--NTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVK 67

  Fly   120 MQSSKRTLRSHEIPINGLALTSSASLQGNSPMSVAGGVGGGGVGTPGSVGTGGGLGVAVPLTETE 184
            ||.|||.||||||.:               |.|             |.|             ||:
Human    68 MQGSKRILRSHEIVL---------------PPS-------------GQV-------------ETD 91

  Fly   185 LDLHFSLQYPHFIKRDGNRLVILLQRRKKYKSRTILGYKTLAEGIIRMDAVLQKSMD--MIIELT 247
            |.|.||||||||:||:||:|.|:|||||:||:||||||||||.|.|.|..|:|...:  .::.|.
Human    92 LALTFSLQYPHFLKREGNKLQIMLQRRKRYKNRTILGYKTLAAGSISMAEVMQHPSEGGQVLSLC 156

  Fly   248 ASGKNGRPGTVVACLRAERV-----SSIPVDHDNKNNNSVLLADRVAEYSDEDEEAEFSSGEFND 307
            :|.|.       |.::|..:     ||.|:||::....:...|.....||:|:.|:..|..|.:|
Human   157 SSIKE-------APVKAAEIWIASLSSQPIDHEDSTMQAGPKAKSTDNYSEEEYESFSSEQEASD 214

  Fly   308 EANELGLIRGYDPKDPRDYNHPAKHDMRKYRNKLQRSGIEDCALVGHHPGSIQHHHPGVVVDSDS 372
            :|     ::|.|                                                :|.|
Human   215 DA-----VQGQD------------------------------------------------LDED- 225

  Fly   373 EFEMKDKSSSRAKFSRTISL-QQRNFKQKIVALLKRFKVSEELEGESGHRGTAALRGERDLDALF 436
            :|::......|....||.|: :|:|||||:||||:|||||:|:..............|.|||.|:
Human   226 DFDVGKPKKQRRSIVRTTSMTRQQNFKQKVVALLRRFKVSDEVLDSEQDPAEHIPEAEEDLDLLY 290

  Fly   437 QELESLSCCEGDDSGPDM-DSISVGSTPKPSLRPFFTNSRIMLHDNITGNGGDLSQLVGGGLGPG 500
               ::|......|||||| |..||.|||||.|||:|
Human   291 ---DTLDMEHPSDSGPDMEDDDSVLSTPKPKLRPYF----------------------------- 323

  Fly   501 TGTAGNSERRSSDKSDQLTNSSYNLENNKNQKCIHLTNNNNSATTPDR----GGNDSSGNEGNAG 561
                   |..|...|.....|.::..::|...        :.|..|::    ||...|.:..:..
Human   324 -------EGLSHSSSQTEIGSIHSARSHKEPP--------SPADVPEKTRSLGGRQPSDSVSDTV 373

  Fly   562 YTDG------QNSDPQNSPPRDKDYLRLQQMQQQQLTPVSSVAASMGSGSVITPAQTEKRSRLFR 620
            ...|      ....|::||..:...|   .:..::|.|         ||.:     |:..|.:..
Human   374 ALQGVPGPREHPGQPEDSPEAEASTL---DVFTERLPP---------SGRI-----TKTESLVIP 421

  Fly   621 TSSNTPANAGSGGNSVS---AISASGGGKRKHTLSLSAEP--RSVLEACLSPTNVEPRKLLLDQL 680
            ::.:....||..|.|.|   ..:|....:|.::|.....|  ||.|:..|.    .|||.:.|||
Human   422 STRSEGKQAGRRGRSTSLKERQAARPQNERANSLDNERCPDARSQLQVQLQ----IPRKTVYDQL 482

  Fly   681 SRVFAGEDSAIPEVVTIISPPEALGGSALLAKLVTLFANSFKPAFVPQNTAEVKAVLQALMAKIQ 745
            :.:...:|. :||.:.:::..:..|     ..|..:......|.....:.|:|:|....::::||
Human   483 NHILISDDQ-LPENIILVNTSDWQG-----QFLSDVLQRHTLPVVCTCSPADVQAAFSTIVSRIQ 541

  Fly   746 KYCNSNAKPPHTVKVLLIGGDWLQGATLRHYVELMGVRPPDWLNHLRFYLVPVGGSCGSVARHLS 810
            :|||.|::||..||:.:.|......|.||.:||.:..:.||||.::||.::|:|..  .|||:|.
Human   542 RYCNCNSQPPTPVKIAVAGAQHYLSAILRLFVEQLSHKTPDWLGYMRFLVIPLGSH--PVARYLG 604

  Fly   811 QMDQAYAVMFGSDNWTQLCERAAATAAAVSAVTTVNATALTTNLADAAGVAKSDIAELVQRIQRY 875
            .:|..|...|....|..|..:..|.:|.                        .|..::|.||.:|
Human   605 SVDYRYNNFFQDLAWRDLFNKLEAQSAV------------------------QDTPDIVSRITQY 645

  Fly   876 LLAAGPCTQIPIAEAMVNYK---------------DEDSCQIFVPFVSDVRIGYLDAQASLDLEE 925
            :..|....|:||||||:.||               ||:|.|.|:|||..|::|.::.
Human   646 IAGANCAHQLPIAEAMLTYKQKRKKHFHFDFTLSPDEESSQKFIPFVGVVKVGIVEP-------- 702

  Fly   926 NAAGSNAVGSGLGSGSASSSAIPIGSQSSPNVHGVVSGSPPQQQSLGRISPPLQTPPSSASSHRE 990
                     |...||. |..|.|.||       |.:|.:||......:.:.|  |||||.|
Human   703 ---------SSATSGD-SDDAAPSGS-------GTLSSTPPSASPAAKEASP--TPPSSPS---- 744

  Fly   991 RNTSESLSTPSSVQQQSFSGALAAAEAVELQVDYWPLVRPGEGHAKESKGGLSKGSDAGGKNSIK 1055
              .|..||:||..         ..||.:.||||||...:|.:......|..|..     .||::|
Human   745 --VSGGLSSPSQG---------VGAELMGLQVDYWTAAQPADRKRDAEKKDLPV-----TKNTLK 793

  Fly  1056 STFRNLQVWRLPQHAQQLGDMFNGLTVSFATKEKKQKQIMRLGKKKDKERDLE-KEQCVEGVARL 1119
            .|||:|||.|||...:........:||  .||| |.|::|.| .||.|::|:| |.||:||::||
Human   794 CTFRSLQVSRLPSSGEAAATPTMSMTV--VTKE-KNKKVMFL-PKKAKDKDVESKSQCIEGISRL 854

  Fly  1120 ICSPKQSHPVPLRVYIDGTEWTGVKFFQVSSQWQTHVKNFPIALIG 1165
            ||:.:|...: |||.|||.|.:.|||||:::||.:|||:|||.:.|
Human   855 ICTARQQQNM-LRVLIDGVECSDVKFFQLAAQWSSHVKHFPICIFG 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KrT95D	NP_524473.2	Pacs-1	676..1167	CDD:287256	164/506 (32%)
PACS2	XP_006720153.1	Pacs-1	478..901	CDD:287256	164/506 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147150
Domainoid	1	1.000	225	1.000	Domainoid score	I2541
eggNOG	1	0.900	-	-		E1_KOG3709
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15016
Inparanoid	1	1.050	432	1.000	Inparanoid score	I1718
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45439
OrthoDB	1	1.010	-	-		D151297at33208
OrthoFinder	1	1.000	-	-		FOG0002262
OrthoInspector	1	1.000	-	-		otm41468
orthoMCL	1	0.900	-	-		OOG6_102151
Panther	1	1.100	-	-	O	PTHR13280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4164
SonicParanoid	1	1.000	-	-		X1495
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800