DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KrT95D and Pacs2

DIOPT Version :9

Sequence 1:	NP_524473.2	Gene:	KrT95D / 42843	FlyBaseID:	FBgn0020647	Length:	1175	Species:	Drosophila melanogaster
Sequence 2:	XP_006515832.1	Gene:	Pacs2 / 217893	MGIID:	1924399	Length:	916	Species:	Mus musculus

Alignment Length:	1158	Identity:	360/1158 - (31%)
Similarity:	515/1158 - (44%)	Gaps:	299/1158 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GTAGLSAGAGMTTGQKPVPMKLFAAWEVDRTPPNCIPRLCSLTITRLSILTPLPGDTTSLSLAVK 119
            |..||....|..  ..||||.|||.||||.:.|:|:|||||||:.:|::|..|..:..|:.:|||
Mouse     5 GRLGLPGAPGAL--NTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLAVLRELEKELLSVVIAVK 67

  Fly   120 MQSSKRTLRSHEIPINGLALTSSASLQGNSPMSVAGGVGGGGVGTPGSVGTGGGLGVAVPLTETE 184
            ||.|||.||||||.:               |.|             |.|             ||:
Mouse    68 MQGSKRVLRSHEIVL---------------PPS-------------GQV-------------ETD 91

  Fly   185 LDLHFSLQYPHFIKRDGNRLVILLQRRKKYKSRTILGYKTLAEGIIRMDAVLQKSMD--MIIELT 247
            |.|.||||||||:||:||:|.|:|||||:||:||||||||||.|.|.|..|:|...:  .::.|.
Mouse    92 LALTFSLQYPHFLKREGNKLQIMLQRRKRYKNRTILGYKTLAAGSINMAEVMQHPSEGGQVLSLC 156

  Fly   248 ASGKNGRPGTVVACLRAERVSSIPVDHDNKNNNSVLLADRVAEYSDEDEEAEFSSGEFNDEANEL 312
            :|.|..  ...||.:....:||.|:||::....:.........||:|:.|:..|..|.:|:|
Mouse   157 SSIKEA--SVKVAEIWIVSLSSQPIDHEDSAMQAGPKTKSTDNYSEEEYESFSSEQEASDDA--- 216

  Fly   313 GLIRGYDPKDPRDYNHPAKHDMRKYRNKLQRSGIEDCALVGHHPGSIQHHHPGVVVDSDSEFEMK 377
              ::|.|                                                :|.| :|::.
Mouse   217 --VQGQD------------------------------------------------LDED-DFDVG 230

  Fly   378 DKSSSRAKFSRTISL-QQRNFKQKIVALLKRFKVSEELEGESGHRGTAALRGERDLDALFQELES 441
            .....|....||.|: :|:|||||:||||:|||||||:..............|.|||.|:   ::
Mouse   231 KPKKQRRSIVRTTSMTRQQNFKQKVVALLRRFKVSEEVLDSEQDPAEHVPEVEEDLDLLY---DT 292

  Fly   442 LSCCEGDDSGPDM-DSISVGSTPKPSLRPFFTNSRIMLHDNITGNGGDLSQLVGGGLGPG----- 500
            |......|||||| |..||.|||||.|||:|..   :.|.:.....|.:.........|.
Mouse   293 LDVENPSDSGPDMDDDDSVLSTPKPKLRPYFEG---LSHSSSQTEIGSIHSARSHREPPSPADVP 354

  Fly   501 --TGTAGNSERRSSDKSDQLTNSSYNLENNKNQKCIHLTNNNNSATTPDRGGNDSSGNEGNAGYT 563
              |.:.|..::.|...||.:.                     .||..|    .:.||
Mouse   355 EKTRSLGGKQQLSDSVSDTVA---------------------LSAAVP----REPSG-------- 386

  Fly   564 DGQNSDPQNSPPRDKDYLRLQQMQQQQLTPVSSVAASMGSGSVITPAQTEKRSRLFRTSSNTPAN 628
                 .|::||..:...|   .:..::|.|         ||.:|   :||  |.:..::.:....
Mouse   387 -----QPEDSPEAETSTL---DVFTEKLPP---------SGRII---KTE--SLVIPSTRSESKP 429

  Fly   629 AGSGGNSVSAIS---ASGGGKRKHTLSLSAEP--RSVLEACLSPTNVEPRKLLLDQLSRVFAGED 688
            ||..|.|.|...   |....:|.::|.....|  ||.|:..:      |||.:.|||:.:...:|
Mouse   430 AGRRGRSTSLKERQPARPQNERANSLDNERCPDTRSQLQVRI------PRKTVYDQLNHILISDD 488

  Fly   689 SAIPEVVTIISPPEALGG--SALLAKLVTLFANSFKPAFVPQNTAEVKAVLQALMAKIQKYCNSN 751
            . :||.:.:::..:..|.  |.:|.| .||      |.....:.|:|:|....::::||:|||.|
Mouse   489 Q-LPENIILVNTSDWQGQFLSDVLQK-HTL------PVVCTCSAADVQAAFSTIVSRIQRYCNCN 545

  Fly   752 AKPPHTVKVLLIGGDWLQGATLRHYVELMGVRPPDWLNHLRFYLVPVGGSCGSVARHLSQMDQAY 816
            ::||..||:.:.|......|.||.:||.:..:.||||.::||.::|:|..  .|||:|..:|..|
Mouse   546 SQPPTPVKIAVAGAQHYLSAILRLFVEQLSHKTPDWLGYMRFLIIPLGSH--PVARYLGSVDYRY 608

  Fly   817 AVMFGSDNWTQLCERAAATAAAVSAVTTVNATALTTNLADAAGVAKSDIAELVQRIQRYLLAAGP 881
            ...|....|..|..:..|.::.                        .|..::|.||.:|:..|..
Mouse   609 NNFFQDLAWRDLFNKLEAQSSV------------------------QDTPDIVSRITQYISGANC 649

  Fly   882 CTQIPIAEAMVNYK---------------DEDSCQIFVPFVSDVRIGYLD--AQASLDLEENAAG 929
            ..|:||||||:.||               ||:|.|.|:|||..|::|.::  :..|.|.::.|..
Mouse   650 AHQLPIAEAMLTYKQKRKKHFHFDFTLSPDEESSQRFIPFVGVVKVGIVEPSSATSGDSDDAAPS 714

  Fly   930 SNAVGSGLGSGSASSSAIPIGSQSSPNVHGVVSGSPPQQQSLGRISPPLQTPPSSASSHRERNTS 994
            |:::   |.|...|:|..|...::||                        |||||.|      .|
Mouse   715 SSSI---LSSTPPSASTSPAAKEASP------------------------TPPSSPS------VS 746

  Fly   995 ESLSTPSSVQQQSFSGALAAAEAVELQVDYWPLVRPGEGHAKESKGGLSKGSDAGGKNSIKSTFR 1059
            ..||:||..         ..||.:.||||||...:|.     :.|....|......||::|.|||
Mouse   747 GGLSSPSQG---------VGAELMGLQVDYWTAAQPA-----DRKRDAEKKDMPTTKNTLKCTFR 797

  Fly  1060 NLQVWRLPQHAQQLGDMFNGLTVSFATKEKKQKQIMRLGKK-KDKERDLEKEQCVEGVARLICSP 1123
            :|||.|||...:........:||  .||| |.|::|.|.|| ||||.: .|.||:||::||||:.
Mouse   798 SLQVSRLPSSGEAAATPTMSMTV--VTKE-KNKKVMFLPKKTKDKEVE-SKSQCIEGISRLICTA 858

  Fly  1124 KQSH-----------PVPLRVYIDGTEWTGVKFFQVSSQWQTHVKNFPIALIG 1165
            |...           |.| .|.|||.|.:.|||||:::||.:|||:|||.:.|
Mouse   859 KHQQNMLRGRQMVRWPSP-TVLIDGVECSDVKFFQLAAQWSSHVKHFPICIFG 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KrT95D	NP_524473.2	Pacs-1	676..1167	CDD:287256	166/521 (32%)
Pacs2	XP_006515832.1	Pacs-1	476..912	CDD:370924	166/521 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837094
Domainoid	1	1.000	223	1.000	Domainoid score	I2563
eggNOG	1	0.900	-	-		E1_KOG3709
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15016
Inparanoid	1	1.050	432	1.000	Inparanoid score	I1706
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45439
OrthoDB	1	1.010	-	-		D151297at33208
OrthoFinder	1	1.000	-	-		FOG0002262
OrthoInspector	1	1.000	-	-		otm43516
orthoMCL	1	0.900	-	-		OOG6_102151
Panther	1	1.100	-	-	O	PTHR13280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4164
SonicParanoid	1	1.000	-	-		X1495
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800