DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab7 and YPT7

DIOPT Version :9

Sequence 1:	NP_001247276.1	Gene:	Rab7 / 42841	FlyBaseID:	FBgn0015795	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_013713.1	Gene:	YPT7 / 855012	SGDID:	S000004460	Length:	208	Species:	Saccharomyces cerevisiae

Alignment Length:	214	Identity:	127/214 - (59%)
Similarity:	161/214 - (75%)	Gaps:	13/214 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGRKKSLLKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVN-DRVVTMQIWDT 64
            ||.|||::|||||||||.|||||||::|||.::|.||||||||||.||||.|: |:|.|||:|||
Yeast     1 MSSRKKNILKVIILGDSGVGKTSLMHRYVNDKYSQQYKATIGADFLTKEVTVDGDKVATMQVWDT 65

  Fly    65 AGQERFQSLGVAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQASPRDPDHFPFVVLGNKVDL 129
            |||||||||||||||||||||||||||..:||:|:.|||||||:.|:...|:.||||:||||:|.
Yeast    66 AGQERFQSLGVAFYRGADCCVLVYDVTNASSFENIKSWRDEFLVHANVNSPETFPFVILGNKIDA 130

  Fly   130 DNRQ--VSTRRAQQWCQSKNDIPYYETSAKEGINVEMAFQVIAKNALEL-EAEAEVI-NDFPD-- 188
            :..:  ||.:.||:..:|..|||.:.||||..|||:.||:.||::||:. :|:.|.. :|:.|
Yeast   131 EESKKIVSEKSAQELAKSLGDIPLFLTSAKNAINVDTAFEEIARSALQQNQADTEAFEDDYNDAI 195

  Fly   189 QITLGSQNNRPGNPDNCQC 207
            .|.|..:||      :|.|
Yeast   196 NIRLDGENN------SCSC 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_001247276.1	Rab7	9..179	CDD:206655	112/173 (65%)
Rab7	NP_001247276.1	RAB	9..174	CDD:197555	110/167 (66%)
YPT7	NP_013713.1	Rab7	9..182	CDD:206655	112/172 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I440
eggNOG	1	0.900	-	-		E1_KOG0394
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I691
Isobase	1	0.950	-	0	Normalized mean entropy	S534
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001661
OrthoInspector	1	1.000	-	-		oto99536
orthoMCL	1	0.900	-	-		OOG6_101358
Panther	1	1.100	-	-	LDO	PTHR47981
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2001
SonicParanoid	1	1.000	-	-		X1058
TreeFam	1	0.960	-	-
	13	12.800