DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab7 and RAB5B

DIOPT Version :9

Sequence 1:	NP_001247276.1	Gene:	Rab7 / 42841	FlyBaseID:	FBgn0015795	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_001238965.1	Gene:	RAB5B / 5869	HGNCID:	9784	Length:	215	Species:	Homo sapiens

Alignment Length:	171	Identity:	69/171 - (40%)
Similarity:	99/171 - (57%)	Gaps:	6/171 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDRVVTMQIWDTAGQERFQSLG 74
            |:::||:|:|||:||:.::|..:|....::||||.|.|:.|.::|..|..:|||||||||:.||.
Human    22 KLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLA 86

  Fly    75 VAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQASPRDPDHFPFVVLGNKVDLDN-RQVSTRR 138
            ..:||||...::|||:|...:|....:|..|...||||    .....:.|||.||.| |.|....
Human    87 PMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASP----SIVIALAGNKADLANKRMVEYEE 147

  Fly   139 AQQWCQSKNDIPYYETSAKEGINVEMAFQVIAKNALELEAE 179
            ||.:... |.:.:.|||||..:||...|..|||...:.|.:
Human   148 AQAYADD-NSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQ 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_001247276.1	Rab7	9..179	CDD:206655	69/169 (41%)
Rab7	NP_001247276.1	RAB	9..174	CDD:197555	68/164 (41%)
RAB5B	NP_001238965.1	Rab5_related	20..182	CDD:206653	68/164 (41%)
		Effector region. /evidence=ECO:0000255	49..57		4/7 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..215		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910