Protein Alignment Rab7 and RAB5A

DIOPT Version :10

• Sequence 1: NP_524472.1
• Gene: Rab7 / 42841
• FlyBaseID: FBgn0015795
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_004153.2
• Gene: RAB5A / 5868
• HGNCID: 9783
• Length: 215
• Species: Homo sapiens
• Alignment Length: 207
• Identity: 78/207 - (37%)
• Similarity: 111/207 - (53%)
• Gaps: 9/207 - (4%)

  Fly     2 SGRKKSLLKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDRVVTMQIWDTAG 66
            :|.|....|:::||:|:|||:||:.::|..:|....::||||.|.|:.|.::|..|..:||||||
Human    14 TGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAG 78

  Fly    67 QERFQSLGVAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQASPRDPDHFPFVVLGNKVDLDN 131
            |||:.||...:||||...::|||:|...||....:|..|...||||    :....:.|||.||.|
Human    79 QERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASP----NIVIALSGNKADLAN 139

  Fly   132 -RQVSTRRAQQWCQSKNDIPYYETSAKEGINVEMAFQVIAKNALELEAEAEVINDFPDQITLGSQ 195
             |.|..:.||.:... |.:.:.|||||..:||...|..|||...:.|.:....|....:   |..
Human   140 KRAVDFQEAQSYADD-NSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGR---GVD 200

  Fly   196 NNRPGNPDNCQC 207
            ...|..|...||
Human   201 LTEPTQPTRNQC 212

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_524472.1	Rab7	9..179	CDD:206655	70/170 (41%)
RAB5A	NP_004153.2	Rab5_related	20..182	CDD:206653	69/166 (42%)
		Switch 1. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	44..56		4/11 (36%)
		Switch 2. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	77..93		9/15 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..215		7/35 (20%)