DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab7 and RAB2A

DIOPT Version :9

Sequence 1:	NP_001247276.1	Gene:	Rab7 / 42841	FlyBaseID:	FBgn0015795	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_002856.1	Gene:	RAB2A / 5862	HGNCID:	9763	Length:	212	Species:	Homo sapiens

Alignment Length:	190	Identity:	67/190 - (35%)
Similarity:	111/190 - (58%)	Gaps:	5/190 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDRVVTMQIWDTAGQERFQS 72
            |.|.||:||:.|||:.|:.|:.:|||...:..|||.:|..:.:.::.:.:.:|||||||||.|:|
Human     6 LFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRS 70

  Fly    73 LGVAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQASPRDPDHFPFVVLGNKVDLDNRQVSTR 137
            :..::||||...:||||:|..::|.:|.:|.::    |......:...:::|||.||::|:...:
Human    71 ITRSYYRGAAGALLVYDITRRDTFNHLTTWLED----ARQHSNSNMVIMLIGNKSDLESRREVKK 131

  Fly   138 RAQQWCQSKNDIPYYETSAKEGINVEMAFQVIAKNALELEAEAEV-INDFPDQITLGSQN 196
            ...:....::.:.:.|||||...|||.||...||...|...|... ||:..:.|.:|.|:
Human   132 EEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQH 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_001247276.1	Rab7	9..179	CDD:206655	60/169 (36%)
Rab7	NP_001247276.1	RAB	9..174	CDD:197555	59/164 (36%)
RAB2A	NP_002856.1	PLN03108	1..188	CDD:178655	65/185 (35%)
		Required for interaction with PRKCI. /evidence=ECO:0000269\|PubMed:14570876	2..19		7/12 (58%)
		Effector region. /evidence=ECO:0000250	35..43		3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910