DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab7 and RAB1A

DIOPT Version :9

Sequence 1:	NP_001247276.1	Gene:	Rab7 / 42841	FlyBaseID:	FBgn0015795	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_004152.1	Gene:	RAB1A / 5861	HGNCID:	9758	Length:	205	Species:	Homo sapiens

Alignment Length:	164	Identity:	62/164 - (37%)
Similarity:	102/164 - (62%)	Gaps:	6/164 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDRVVTMQIWDTAGQERFQS 72
            |.|::::|||.|||:.|:.::.:..::..|.:|||.||..:.:.::.:.:.:|||||||||||::
Human    11 LFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRT 75

  Fly    73 LGVAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQASPRDPDHFPFVVLGNKVDLDNRQ-VST 136
            :..::||||...::|||||...||.|:..|..|....||    ::...:::|||.||..:: |..
Human    76 ITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYAS----ENVNKLLVGNKCDLTTKKVVDY 136

  Fly   137 RRAQQWCQSKNDIPYYETSAKEGINVEMAFQVIA 170
            ..|:::..|.. ||:.|||||...|||.:|..:|
Human   137 TTAKEFADSLG-IPFLETSAKNATNVEQSFMTMA 169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_001247276.1	Rab7	9..179	CDD:206655	61/163 (37%)
Rab7	NP_001247276.1	RAB	9..174	CDD:197555	61/163 (37%)
RAB1A	NP_004152.1	Rab1_Ypt1	10..175	CDD:206661	62/164 (38%)
		Effector region. /evidence=ECO:0000255	40..48		4/7 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..205
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910