DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rab7 and RABL6

DIOPT Version :9

Sequence 1:	NP_001247276.1	Gene:	Rab7 / 42841	FlyBaseID:	FBgn0015795	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_001167459.1	Gene:	RABL6 / 55684	HGNCID:	24703	Length:	730	Species:	Homo sapiens

Alignment Length:	231	Identity:	43/231 - (18%)
Similarity:	90/231 - (38%)	Gaps:	70/231 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVV---------NDRVVTMQIWDT 64
            :|::|.||.:.|||:|.::...:.|..:|       ..|:|:.|         .|.:|.:::||.
Human    44 MKIVIRGDRNTGKTALWHRLQGRPFVEEY-------IPTQEIQVTSIHWSYKTTDDIVKVEVWDV 101

  Fly    65 AGQERFQSLG----------------------VAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFL 107
            ..:.:.:..|                      :..|:..:..|:::|:|        ..|...::
Human   102 VDKGKCKKRGDGLKMENDPQEAESEMALDAEFLDVYKNCNGVVMMFDIT--------KQWTFNYI 158

  Fly   108 IQASPRDPDHFPFVVLGNKVDL-DNRQVSTRRAQQWCQSKNDIP-------YYETSAKEGINV-- 162
            ::..|:.|.|.|..||||..|: ::|.:.....:.:..:.:..|       |.|:|.|....:
Human   159 LRELPKVPTHVPVCVLGNYRDMGEHRVILPDDVRDFIDNLDSRPPGSSYFRYAESSMKNSFGLKY 223

  Fly   163 --------------EMAFQVIAKNALELEAEAEVIN 184
                          |...:.:..|.|:::|..|.::
Human   224 LHKFFNIPFLQLQRETLLRQLETNQLDMDATLEELS 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_001247276.1	Rab7	9..179	CDD:206655	41/224 (18%)
Rab7	NP_001247276.1	RAB	9..174	CDD:197555	40/219 (18%)
RABL6	NP_001167459.1	P-loop_NTPase	44..222	CDD:304359	38/192 (20%)
		Ras	45..222	CDD:278499	38/191 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..730
		Interaction with CDKN2A. /evidence=ECO:0000269\|PubMed:16582619	656..694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910