DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab7 and DIRAS2

DIOPT Version :9

Sequence 1:	NP_001247276.1	Gene:	Rab7 / 42841	FlyBaseID:	FBgn0015795	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_060064.2	Gene:	DIRAS2 / 54769	HGNCID:	19323	Length:	199	Species:	Homo sapiens

Alignment Length:	182	Identity:	52/182 - (28%)
Similarity:	88/182 - (48%)	Gaps:	25/182 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDR-VVTMQIWDTAGQERFQSL 73
            :|.:.|...|||:||:.::|...|...|..|:...:  ::|:..|: :.|:||.||.|..:|.::
Human     9 RVAVFGAGGVGKSSLVLRFVKGTFRESYIPTVEDTY--RQVISCDKSICTLQITDTTGSHQFPAM 71

  Fly    74 -------GVAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQASPRDPDHFPFVVLGNKVD-LD 130
                   |.||       :|||.:|:..|.:.|....::  |.....|.:..|.:::|||.| ..
Human    72 QRLSISKGHAF-------ILVYSITSRQSLEELKPIYEQ--ICEIKGDVESIPIMLVGNKCDESP 127

  Fly   131 NRQVSTRRAQQWCQSKNDIPYYETSAKEGINVEMAFQVIAKNALELEAEAEV 182
            :|:|.:..|:...::.. ..:.|||||...||:..||.:    |.||....|
Human   128 SREVQSSEAEALARTWK-CAFMETSAKLNHNVKELFQEL----LNLEKRRTV 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_001247276.1	Rab7	9..179	CDD:206655	51/177 (29%)
Rab7	NP_001247276.1	RAB	9..174	CDD:197555	48/172 (28%)
DIRAS2	NP_060064.2	ARHI_like	7..170	CDD:206711	50/176 (28%)
DIRAS2	NP_060064.2	Effector region. /evidence=ECO:0000255	36..44		2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910