DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab7 and rab4a

DIOPT Version :9

Sequence 1:	NP_001247276.1	Gene:	Rab7 / 42841	FlyBaseID:	FBgn0015795	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_001119853.1	Gene:	rab4a / 403031	ZFINID:	ZDB-GENE-040525-1	Length:	213	Species:	Danio rerio

Alignment Length:	186	Identity:	70/186 - (37%)
Similarity:	113/186 - (60%)	Gaps:	12/186 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGRKKSLLKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDRVVTMQIWDTA 65
            ||.....|.|.:::|::..||:.|::|::.|||.:....|||.:|.:|.:.|.::.|.:||||||
Zfish     1 MSETYDFLFKFLVIGNAGTGKSCLLHQFIEKRFKDDSNHTIGVEFGSKIISVVNKFVKLQIWDTA 65

  Fly    66 GQERFQSLGVAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQASPRDPDHFPFVVLGNKVDLD 130
            |||||:|:..::||||...:||||:|:..::..|.:|..:..:.||    .:...::.|||.|||
Zfish    66 GQERFRSVTRSYYRGAAGALLVYDITSRETYNALTNWLTDARMLAS----QNIVIILCGNKKDLD 126

  Fly   131 -NRQVSTRRAQQWCQSKNDIPYYETSAKEGINVEMAFQVIAKNAL------ELEAE 179
             :|:|:...|.::.| :|::.:.||||..|.|||.||...|:..|      ||:.|
Zfish   127 ADREVTFLEASRFAQ-ENELMFLETSALTGENVEEAFVQCARKILNKIESGELDPE 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_001247276.1	Rab7	9..179	CDD:206655	66/176 (38%)
Rab7	NP_001247276.1	RAB	9..174	CDD:197555	63/165 (38%)
rab4a	NP_001119853.1	RAB	9..172	CDD:197555	64/167 (38%)
		Rab4	9..169	CDD:206696	63/164 (38%)
		Effector region. /evidence=ECO:0000250	37..45		3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910