DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab7 and RAB37

DIOPT Version :9

Sequence 1:	NP_001247276.1	Gene:	Rab7 / 42841	FlyBaseID:	FBgn0015795	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_001157461.1	Gene:	RAB37 / 326624	HGNCID:	30268	Length:	228	Species:	Homo sapiens

Alignment Length:	193	Identity:	79/193 - (40%)
Similarity:	114/193 - (59%)	Gaps:	11/193 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KVIILGDSSVGKTSLMNQYVNKRF-SNQYKATIGADFCTKEVVVNDRVVTMQIWDTAGQERFQSL 73
            ||::|||:.||||..:.|:.:..| |..:.||:|.||..|.|.|:...|.:|||||||||||:|:
Human    36 KVMLLGDTGVGKTCFLIQFKDGAFLSGTFIATVGIDFRNKVVTVDGVRVKLQIWDTAGQERFRSV 100

  Fly    74 GVAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQASPRDPDHFPFVVLGNKVDLDNRQVSTRR 138
            ..|:||.|...:|:||:|..:||.|:.:|..| :.:.:.||   ...::||||.|:.:.:|....
Human   101 THAYYRDAQALLLLYDITNKSSFDNIRAWLTE-IHEYAQRD---VVIMLLGNKADMSSERVIRSE 161

  Fly   139 AQQWCQSKNDIPYYETSAKEGINVEMAFQVIAKNALELEAEAEVINDFPD-QIT--LGSQNNR 198
            ..:....:..:|:.|||||.|:|||:||..|||   ||:..|....|.|. ||.  :.||..|
Human   162 DGETLAREYGVPFLETSAKTGMNVELAFLAIAK---ELKYRAGHQADEPSFQIRDYVESQKKR 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_001247276.1	Rab7	9..179	CDD:206655	71/169 (42%)
Rab7	NP_001247276.1	RAB	9..174	CDD:197555	69/164 (42%)
RAB37	NP_001157461.1	Rab26	36..225	CDD:206695	79/193 (41%)
RAB37	NP_001157461.1	RAB	36..197	CDD:197555	70/167 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910