DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab7 and Rab12

DIOPT Version :9

Sequence 1:	NP_001247276.1	Gene:	Rab7 / 42841	FlyBaseID:	FBgn0015795	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_037149.1	Gene:	Rab12 / 25530	RGDID:	3527	Length:	243	Species:	Rattus norvegicus

Alignment Length:	197	Identity:	64/197 - (32%)
Similarity:	109/197 - (55%)	Gaps:	22/197 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDRVVTMQIWDTAGQERFQSL 73
            |:|||:|...|||||||.::.:..|....|:|:|.||..|.|.:..:.:.:|||||||||||.|:
  Rat    42 LQVIIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQERFNSI 106

  Fly    74 GVAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQASPRDPDHFPFVVLGNKVDLD-NRQVSTR 137
            ..|:||.|...:||||:|...:|.:|..|. :.:.:.:..|.:   .:::|||:|.: :|::|.:
  Rat   107 TSAYYRSAKGIILVYDITKKETFDDLPKWM-KMIDKYASEDAE---LLLVGNKLDCETDREISRQ 167

  Fly   138 RAQQWCQSKNDIPYYETSAKEGINVEMAF-----------------QVIAKNALELEAEAEVIND 185
            :.:::.|....:.:.|.|||:..||:..|                 ..::.:.|.|:.|.|:..:
  Rat   168 QGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDVLRSELSNSILSLQPEPEIPPE 232

  Fly   186 FP 187
            .|
  Rat   233 LP 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_001247276.1	Rab7	9..179	CDD:206655	61/187 (33%)
Rab7	NP_001247276.1	RAB	9..174	CDD:197555	59/182 (32%)
Rab12	NP_037149.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		Rab12	42..243	CDD:206699	64/197 (32%)
		Effector region. /evidence=ECO:0000250	70..78		3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910