DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab7 and Rabl6

DIOPT Version :9

Sequence 1:	NP_001247276.1	Gene:	Rab7 / 42841	FlyBaseID:	FBgn0015795	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_001019787.2	Gene:	Rabl6 / 227624	MGIID:	2442633	Length:	725	Species:	Mus musculus

Alignment Length:	230	Identity:	45/230 - (19%)
Similarity:	91/230 - (39%)	Gaps:	69/230 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVV---------NDRVVTMQIWDT 64
            :|::|.||.:.|||:|.::...|:|..:|       ..|:|:.|         .|.||.:::||.
Mouse    44 MKIVIRGDRNTGKTALWHRLQGKKFVEEY-------IPTQEIQVTSIHWNYKTTDDVVKVEVWDV 101

  Fly    65 AGQERFQSLG----------------------VAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFL 107
            ..:.:.:..|                      :..|:..:..|:::|:|        ..|...::
Mouse   102 VDKGKCKKRGDGLKTENDPQEAESELALDAEFLDVYKNCNGVVMMFDIT--------KQWTFNYV 158

  Fly   108 IQASPRDPDHFPFVVLGNKVDL-DNRQVSTRRAQQWCQSKNDIP------YYETSAKEGINV--- 162
            ::..|:.|.|.|..||||..|: ::|.:.....:.:.:..:..|      |.|:|.|....:
Mouse   159 LRELPKVPTHVPVCVLGNYRDMGEHRVILPDDVRDFIEHLDRPPGSSYFRYAESSMKNSFGLKYL 223

  Fly   163 -------------EMAFQVIAKNALELEAEAEVIN 184
                         |...:.:..|.|:::|..|.::
Mouse   224 HKFFNIPFLQLQRETLLRQLETNQLDIDATLEELS 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_001247276.1	Rab7	9..179	CDD:206655	43/223 (19%)
Rab7	NP_001247276.1	RAB	9..174	CDD:197555	42/218 (19%)
Rabl6	NP_001019787.2	Small GTPase-like	39..279		45/230 (20%)
		P-loop_NTPase	44..221	CDD:304359	40/191 (21%)
		Ras	45..221	CDD:278499	40/190 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..364
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..725
		Interaction with CDKN2A. /evidence=ECO:0000250	652..690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910