DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rab7 and DIRAS1

DIOPT Version :9

Sequence 1:NP_001247276.1 Gene:Rab7 / 42841 FlyBaseID:FBgn0015795 Length:207 Species:Drosophila melanogaster
Sequence 2:XP_011526015.1 Gene:DIRAS1 / 148252 HGNCID:19127 Length:232 Species:Homo sapiens


Alignment Length:182 Identity:59/182 - (32%)
Similarity:91/182 - (50%) Gaps:36/182 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 KVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDR-VVTMQIWDTAGQERFQSL 73
            :|::.|...|||:||:.::|...|.:.|..||...:  ::|:..|: |.|:||.||.|..:|.::
Human    43 RVVVFGAGGVGKSSLVLRFVKGTFRDTYIPTIEDTY--RQVISCDKSVCTLQITDTTGSHQFPAM 105

  Fly    74 -------GVAFYRGADCCVLVYDVTAPNSFKNLDS-WRDEFLIQASPRDPDHFPFVVLGNKVDLD 130
                   |.||       :||:.||:..|.:.|.. ::....|:.|..|   .|.:::|||.|..
Human   106 QRLSISKGHAF-------ILVFSVTSKQSLEELGPIYKLIVQIKGSVED---IPVMLVGNKCDET 160

  Fly   131 NRQVSTRR----AQQW-CQSKNDIPYYETSAKEGINVEMAFQVIAKNALELE 177
            .|:|.||.    ||:| |      .:.|||||...||:..||.:    |.||
Human   161 QREVDTREAQAVAQEWKC------AFMETSAKMNYNVKELFQEL----LTLE 202

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rab7NP_001247276.1 Rab7 9..179 CDD:206655 59/182 (32%)
RAB 9..174 CDD:197555 56/177 (32%)
DIRAS1XP_011526015.1 PTZ00369 39..232 CDD:240385 59/182 (32%)
P-loop_NTPase 41..202 CDD:304359 57/180 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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