DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab7 and ARL8A

DIOPT Version :9

Sequence 1:	NP_001247276.1	Gene:	Rab7 / 42841	FlyBaseID:	FBgn0015795	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_620150.1	Gene:	ARL8A / 127829	HGNCID:	25192	Length:	186	Species:	Homo sapiens

Alignment Length:	181	Identity:	44/181 - (24%)
Similarity:	84/181 - (46%)	Gaps:	30/181 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KSLLKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDRVVTMQIWDTAGQERF 70
            |..:::.::|....|||:.:|...:.:|:.....|:|  |..:::...:  ||:::||..||.||
Human    18 KEEMELTLVGLQYSGKTTFVNVIASGQFNEDMIPTVG--FNMRKITKGN--VTIKLWDIGGQPRF 78

  Fly    71 QSLGVAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQASPRDPDH---------FPFVVLGNK 126
            :|:...:.||....|.:.|..            |:..|:||..:..:         .|.:|||||
Human    79 RSMWERYCRGVSAIVYMVDAA------------DQEKIEASKNELHNLLDKPQLQGIPVLVLGNK 131

  Fly   127 VD----LDNRQVSTRRAQQWCQSKNDIPYYETSAKEGINVEMAFQVIAKNA 173
            .|    ||.:::..:......|.: :|..|..|.||..|:::..|.:.:::
Human   132 RDLPGALDEKELIEKMNLSAIQDR-EICCYSISCKEKDNIDITLQWLIQHS 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_001247276.1	Rab7	9..179	CDD:206655	43/178 (24%)
Rab7	NP_001247276.1	RAB	9..174	CDD:197555	43/178 (24%)
ARL8A	NP_620150.1	Arl10_like	22..180	CDD:206724	43/174 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910