DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab7 and RHEBL1

DIOPT Version :9

Sequence 1:	NP_001247276.1	Gene:	Rab7 / 42841	FlyBaseID:	FBgn0015795	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_653194.1	Gene:	RHEBL1 / 121268	HGNCID:	21166	Length:	183	Species:	Homo sapiens

Alignment Length:	175	Identity:	55/175 - (31%)
Similarity:	84/175 - (48%)	Gaps:	18/175 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDRVVTMQIWDTAGQERFQSLG 74
            ||:|||...||||||.:|:|...||..|..|:...: :|.|.:......:.:.|||||:.:..|.
Human     8 KVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTY-SKIVTLGKDEFHLHLVDTAGQDEYSILP 71

  Fly    75 VAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQA--SPRDPDHFPFVVLGNKVDLD-NRQVST 136
            .:|..|....||||.||:.:||:.::|     |.|.  ........|.|::|||.||. .|:|..
Human    72 YSFIIGVHGYVLVYSVTSLHSFQVIES-----LYQKLHEGHGKTRVPVVLVGNKADLSPEREVQA 131

  Fly   137 ----RRAQQWCQSKNDIPYYETSAKEGINVEMAFQVIAKNALELE 177
                :.|:.|     ...:.|:||:|....:..|..:.:....:|
Human   132 VEGKKLAESW-----GATFMESSARENQLTQGIFTKVIQEIARVE 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_001247276.1	Rab7	9..179	CDD:206655	55/175 (31%)
Rab7	NP_001247276.1	RAB	9..174	CDD:197555	54/170 (32%)
RHEBL1	NP_653194.1	small_GTPase	5..169	CDD:197466	54/171 (32%)
		RheB	6..183	CDD:206709	55/175 (31%)
		Effector region	35..43		2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910