Protein Alignment Rab7 and RAB32

DIOPT Version :10

• Sequence 1: NP_524472.1
• Gene: Rab7 / 42841
• FlyBaseID: FBgn0015795
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_006825.1
• Gene: RAB32 / 10981
• HGNCID: 9772
• Length: 225
• Species: Homo sapiens
• Alignment Length: 217
• Identity: 71/217 - (32%)
• Similarity: 117/217 - (53%)
• Gaps: 30/217 - (13%)

  Fly     5 KKSLLKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDR-VVTMQIWDTAGQE 68
            ::.|.||:::|:..|||||::.:||::.||..|:||||.||..|.:..:.| :|.:|:||.||||
Human    22 REHLFKVLVIGELGVGKTSIIKRYVHQLFSQHYRATIGVDFALKVLNWDSRTLVRLQLWDIAGQE 86

  Fly    69 RFQSLGVAFYRGADCCVLVYDVTAPNSFKNLDSWRDEF-----LIQASPRDPDHFPFVVLGNKVD 128
            ||.::...:|:.|....:|:|::..::|:.:..|:.:.     |...||     .|.|:|.||.|
Human    87 RFGNMTRVYYKEAVGAFVVFDISRSSTFEAVLKWKSDLDSKVHLPNGSP-----IPAVLLANKCD 146

  Fly   129 --LDNRQVSTRRAQQWCQSKNDIPYYETSAKEGINVEMAFQVIAKNALELEAEAEVIN--DFP-- 187
              .|:.| |..:..|:|:......::|||||:.||:|.|.:.:.:..|        :|  .||
Human   147 QNKDSSQ-SPSQVDQFCKEHGFAGWFETSAKDNINIEEAARFLVEKIL--------VNHQSFPNE 202

  Fly   188 ----DQITLGSQNNRPGNPDNC 205
                |:|.|..:..|..|...|
Human   203 ENDVDKIKLDQETLRAENKSQC 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_524472.1	Rab7	9..179	CDD:206655	61/177 (34%)
RAB32	NP_006825.1	Rab32_Rab38	26..224	CDD:206692	69/211 (33%)
		Switch 1. /evidence=ECO:0000269|PubMed:24856514, ECO:0007744|PDB:4CYM, ECO:0007744|PDB:4CZ2	48..62		7/13 (54%)
		Switch 2. /evidence=ECO:0000269|PubMed:24856514, ECO:0007744|PDB:4CYM, ECO:0007744|PDB:4CZ2	84..97		5/12 (42%)
		PKA-RII subunit binding domain	178..197		6/26 (23%)